PCMT1

PCMT1
Protein-L-isoaspartate (D-aspartate) O-methyltransferase

PDB rendering based on 1i1n.
Identifiers
Symbols PCMT1;
External IDs OMIM176851 MGI97502 HomoloGene55895 GeneCards: PCMT1 Gene
EC number 2.1.1.77
RNA expression pattern
PBB GE PCMT1 210156 s at tn.png
PBB GE PCMT1 205202 at tn.png
PBB GE PCMT1 208857 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5110 18537
Ensembl ENSG00000120265 ENSMUSG00000019795
UniProt P22061 Q545L9
RefSeq (mRNA) NM_005389 NM_008786.2
RefSeq (protein) NP_005380 NP_032812.2
Location (UCSC) Chr 6:
150.07 – 150.13 Mb
Chr 10:
7.35 – 7.4 Mb
PubMed search [1] [2]

Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.[1][2][3] Three classes of protein carboxyl methyltransferases, distinguished by their methyl-acceptor substrate specificity, have been found in prokaryotic and eukaryotic cells. The type II enzyme catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to the free carboxyl groups of D-aspartyl and L-isoaspartyl residues. These methyl-accepting residues result from the spontaneous deamidation, isomerization, and racemization of normal L-aspartyl and L-asparaginyl residues and represent sites of covalent damage to aging proteins PCMT1 (EC 2.1.1.77) is a protein repair enzyme that initiates the conversion of abnormal D-aspartyl and L-isoaspartyl residues to the normal L-aspartyl form.[supplied by OMIM][3]

References

  1. ^ MacLaren DC, O'Connor CM, Xia YR, Mehrabian M, Klisak I, Sparkes RS, Clarke S, Lusis AJ (Feb 1993). "The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10". Genomics 14 (4): 852–6. doi:10.1016/S0888-7543(05)80104-1. PMID 1478665. 
  2. ^ DeVry CG, Clarke S (Jun 1999). "Assignment of the protein L-isoaspartate (D-aspartate) O-methyltransferase gene (PCMT1) to human chromosome bands 6q24→q25 with radiation hybrid mapping". Cytogenet Cell Genet 84 (1–2): 130–1. doi:10.1159/000015239. PMID 10343128. 
  3. ^ a b "Entrez Gene: PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5110. 

Further reading




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  • L-isoaspartyl methyltransferase — protein Name=Protein L isoaspartate(D aspartate) O methyltransferase caption= width= HGNCid=8728 Symbol=PIMT AltSymbols= EntrezGene=PCMT1 OMIM=176851 PDB= ECnumber=2.1.1.77 Chromosome=6 Arm=q Band=22.3 24 LocusSupplementaryData=Protein L… …   Wikipedia

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