Adaptor-related protein complex 1, sigma 1 subunit, also known as AP1S1, is a human gene.cite web | title = Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1174| accessdate = ]

section_title =
summary_text = The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.cite web | title = Entrez Gene: AP1S1 adaptor-related protein complex 1, sigma 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1174| accessdate = ]


Further reading

citations =
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*cite journal | author=Geyer M, Fackler OT, Peterlin BM |title=Structure--function relationships in HIV-1 Nef. |journal=EMBO Rep. |volume=2 |issue= 7 |pages= 580–5 |year= 2001 |pmid= 11463741 |doi= 10.1093/embo-reports/kve141
*cite journal | author=Bénichou S, Benmerah A |title= [The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway] |journal=Med Sci (Paris) |volume=19 |issue= 1 |pages= 100–6 |year= 2003 |pmid= 12836198 |doi=
*cite journal | author=Kirchhausen T, Davis AC, Frucht S, "et al." |title=AP17 and AP19, the mammalian small chains of the clathrin-associated protein complexes show homology to Yap17p, their putative homolog in yeast. |journal=J. Biol. Chem. |volume=266 |issue= 17 |pages= 11153–7 |year= 1991 |pmid= 2040623 |doi=
*cite journal | author=Peyrard M, Parveneh S, Lagercrantz S, "et al." |title=Cloning, expression pattern, and chromosomal assignment to 16q23 of the human gamma-adaptin gene (ADTG). |journal=Genomics |volume=50 |issue= 2 |pages= 275–80 |year= 1998 |pmid= 9653655 |doi= 10.1006/geno.1998.5289
*cite journal | author=Takatsu H, Sakurai M, Shin HW, "et al." |title=Identification and characterization of novel clathrin adaptor-related proteins. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24693–700 |year= 1998 |pmid= 9733768 |doi=
*cite journal | author=Craig HM, Pandori MW, Guatelli JC |title=Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11229–34 |year= 1998 |pmid= 9736718 |doi=
*cite journal | author=Bresnahan PA, Yonemoto W, Ferrell S, "et al." |title=A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1235–8 |year= 1999 |pmid= 9811606 |doi=
*cite journal | author=Greenberg M, DeTulleo L, Rapoport I, "et al." |title=A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4. |journal=Curr. Biol. |volume=8 |issue= 22 |pages= 1239–42 |year= 1999 |pmid= 9811611 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Berlioz-Torrent C, Shacklett BL, Erdtmann L, "et al." |title=Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins. |journal=J. Virol. |volume=73 |issue= 2 |pages= 1350–61 |year= 1999 |pmid= 9882340 |doi=
*cite journal | author=Fölsch H, Ohno H, Bonifacino JS, Mellman I |title=A novel clathrin adaptor complex mediates basolateral targeting in polarized epithelial cells. |journal=Cell |volume=99 |issue= 2 |pages= 189–98 |year= 1999 |pmid= 10535737 |doi=
*cite journal | author=Wyss S, Berlioz-Torrent C, Boge M, "et al." |title=The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter] . |journal=J. Virol. |volume=75 |issue= 6 |pages= 2982–92 |year= 2001 |pmid= 11222723 |doi= 10.1128/JVI.75.6.2982-2992.2001
*cite journal | author=Boehm M, Aguilar RC, Bonifacino JS |title=Functional and physical interactions of the adaptor protein complex AP-4 with ADP-ribosylation factors (ARFs). |journal=EMBO J. |volume=20 |issue= 22 |pages= 6265–76 |year= 2002 |pmid= 11707398 |doi= 10.1093/emboj/20.22.6265
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Janvier K, Craig H, Hitchin D, "et al." |title=HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8725–32 |year= 2003 |pmid= 12486136 |doi= 10.1074/jbc.M210115200
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782

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