CUGBP2

CUG triplet repeat, RNA binding protein 2, also known as CUGBP2, is a human gene.cite web | title = Entrez Gene: CUGBP2 CUG triplet repeat, RNA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10659| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: CUGBP2 CUG triplet repeat, RNA binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10659| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hwang DM, Hwang WS, Liew CC |title=Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system. |journal=J. Mol. Cell. Cardiol. |volume=26 |issue= 10 |pages= 1329–33 |year= 1995 |pmid= 7869393 |doi= 10.1006/jmcc.1994.1151
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Lu X, Timchenko NA, Timchenko LT |title=Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. |journal=Hum. Mol. Genet. |volume=8 |issue= 1 |pages= 53–60 |year= 1999 |pmid= 9887331 |doi=
*cite journal | author=Choi DK, Ito T, Tsukahara F, "et al." |title=Developmentally-regulated expression of mNapor encoding an apoptosis-induced ELAV-type RNA binding protein. |journal=Gene |volume=237 |issue= 1 |pages= 135–42 |year= 1999 |pmid= 10524244 |doi=
*cite journal | author=Good PJ, Chen Q, Warner SJ, Herring DC |title=A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. |journal=J. Biol. Chem. |volume=275 |issue= 37 |pages= 28583–92 |year= 2000 |pmid= 10893231 |doi= 10.1074/jbc. M003083200
*cite journal | author=Ladd AN, Charlet N, Cooper TA |title=The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. |journal=Mol. Cell. Biol. |volume=21 |issue= 4 |pages= 1285–96 |year= 2001 |pmid= 11158314 |doi= 10.1128/MCB.21.4.1285-1296.2001
*cite journal | author=Li D, Bachinski LL, Roberts R |title=Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia. |journal=Genomics |volume=74 |issue= 3 |pages= 396–401 |year= 2001 |pmid= 11414768 |doi= 10.1006/geno.2001.6558
*cite journal | author=Anant S, Henderson JO, Mukhopadhyay D, "et al." |title=Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47338–51 |year= 2002 |pmid= 11577082 |doi= 10.1074/jbc. M104911200
*cite journal | author=Lichtner P, Attié-Bitach T, Schuffenhauer S, "et al." |title=Expression and mutation analysis of BRUNOL3, a candidate gene for heart and thymus developmental defects associated with partial monosomy 10p. |journal=J. Mol. Med. |volume=80 |issue= 7 |pages= 431–42 |year= 2003 |pmid= 12110949 |doi= 10.1007/s00109-002-0331-9
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mukhopadhyay D, Houchen CW, Kennedy S, "et al." |title=Coupled mRNA stabilization and translational silencing of cyclooxygenase-2 by a novel RNA binding protein, CUGBP2. |journal=Mol. Cell |volume=11 |issue= 1 |pages= 113–26 |year= 2003 |pmid= 12535526 |doi=
*cite journal | author=Singh G, Charlet-B N, Han J, Cooper TA |title=ETR-3 and CELF4 protein domains required for RNA binding and splicing activity "in vivo". |journal=Nucleic Acids Res. |volume=32 |issue= 3 |pages= 1232–41 |year= 2004 |pmid= 14973222 |doi= 10.1093/nar/gkh275
*cite journal | author=Mukhopadhyay D, Jung J, Murmu N, "et al." |title=CUGBP2 plays a critical role in apoptosis of breast cancer cells in response to genotoxic injury. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 504–9 |year= 2004 |pmid= 15033780 |doi=
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Suzuki Y, Yamashita R, Shirota M, "et al." |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604
*cite journal | author=Murmu N, Jung J, Mukhopadhyay D, "et al." |title=Dynamic antagonism between RNA-binding protein CUGBP2 and cyclooxygenase-2-mediated prostaglandin E2 in radiation damage. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 38 |pages= 13873–8 |year= 2004 |pmid= 15358864 |doi= 10.1073/pnas.0406066101
*cite journal | author=Han J, Cooper TA |title=Identification of CELF splicing activation and repression domains "in vivo". |journal=Nucleic Acids Res. |volume=33 |issue= 9 |pages= 2769–80 |year= 2005 |pmid= 15894795 |doi= 10.1093/nar/gki561
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Chen Z, Eggerman TL, Patterson AP |title=ApoB mRNA editing is mediated by a coordinated modulation of multiple apoB mRNA editing enzyme components. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=292 |issue= 1 |pages= G53–65 |year= 2007 |pmid= 16920700 |doi= 10.1152/ajpgi.00118.2006

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