ELMO1

Engulfment and cell motility 1, also known as ELMO1, is a human gene.cite web | title = Entrez Gene: ELMO1 engulfment and cell motility 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9844| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein to promote phagocytosis and effect cell shape changes. Similarity to a C. elegans protein suggests that this protein may function in apoptosis and in cell migration. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: ELMO1 engulfment and cell motility 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9844| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ohara O, Nagase T, Ishikawa K, "et al." |title=Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. |journal=DNA Res. |volume=4 |issue= 1 |pages= 53–9 |year= 1997 |pmid= 9179496 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Gumienny TL, Brugnera E, Tosello-Trampont AC, "et al." |title=CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. |journal=Cell |volume=107 |issue= 1 |pages= 27–41 |year= 2001 |pmid= 11595183 |doi=
*cite journal | author=Scott MP, Zappacosta F, Kim EY, "et al." |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200
*cite journal | author=Brugnera E, Haney L, Grimsley C, "et al." |title=Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. |journal=Nat. Cell Biol. |volume=4 |issue= 8 |pages= 574–82 |year= 2002 |pmid= 12134158 |doi= 10.1038/ncb824
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Sanui T, Inayoshi A, Noda M, "et al." |title=DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1. |journal=Blood |volume=102 |issue= 8 |pages= 2948–50 |year= 2003 |pmid= 12829596 |doi= 10.1182/blood-2003-01-0173
*cite journal | author=Katoh H, Negishi M |title=RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo. |journal=Nature |volume=424 |issue= 6947 |pages= 461–4 |year= 2003 |pmid= 12879077 |doi= 10.1038/nature01817
*cite journal | author=Grimsley CM, Kinchen JM, Tosello-Trampont AC, "et al." |title=Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 6087–97 |year= 2004 |pmid= 14638695 |doi= 10.1074/jbc.M307087200
*cite journal | author=Wang X, Wu YC, Fadok VA, "et al." |title=Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12. |journal=Science |volume=302 |issue= 5650 |pages= 1563–6 |year= 2003 |pmid= 14645848 |doi= 10.1126/science.1087641
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Janardhan A, Swigut T, Hill B, "et al." |title=HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. |journal=PLoS Biol. |volume=2 |issue= 1 |pages= E6 |year= 2006 |pmid= 14737186 |doi= 10.1371/journal.pbio.0020006
*cite journal | author=Lu M, Kinchen JM, Rossman KL, "et al." |title=PH domain of ELMO functions in trans to regulate Rac activation via Dock180. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 8 |pages= 756–62 |year= 2004 |pmid= 15247908 |doi= 10.1038/nsmb800
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=deBakker CD, Haney LB, Kinchen JM, "et al." |title=Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. |journal=Curr. Biol. |volume=14 |issue= 24 |pages= 2208–16 |year= 2005 |pmid= 15620647 |doi= 10.1016/j.cub.2004.12.029
*cite journal | author=Akakura S, Kar B, Singh S, "et al." |title=C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF. |journal=J. Cell. Physiol. |volume=204 |issue= 1 |pages= 344–51 |year= 2005 |pmid= 15700267 |doi= 10.1002/jcp.20288
*cite journal | author=Lu M, Kinchen JM, Rossman KL, "et al." |title=A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs. |journal=Curr. Biol. |volume=15 |issue= 4 |pages= 371–7 |year= 2005 |pmid= 15723800 |doi= 10.1016/j.cub.2005.01.050
*cite journal | author=Shimazaki A, Kawamura Y, Kanazawa A, "et al." |title=Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy. |journal=Diabetes |volume=54 |issue= 4 |pages= 1171–8 |year= 2005 |pmid= 15793258 |doi=
*cite journal | author=Yokoyama N, deBakker CD, Zappacosta F, "et al." |title=Identification of tyrosine residues on ELMO1 that are phosphorylated by the Src-family kinase Hck. |journal=Biochemistry |volume=44 |issue= 24 |pages= 8841–9 |year= 2005 |pmid= 15952790 |doi= 10.1021/bi0500832

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