PDCD4

Programmed cell death 4 (neoplastic transformation inhibitor)
PDB rendering based on 2ggf.
Available structures PDB 2GGF, 2RG8, 2ZU6, 3EIJ
Identifiers
Symbols	PDCD4; H731; MGC33046; MGC33047
External IDs	OMIM: 608610 MGI: 107490 HomoloGene: 7879 GeneCards: PDCD4 Gene
Gene Ontology Molecular function • RNA binding • protein binding Cellular component • nucleus • nucleus • nucleus • nucleolus • cytoplasm • cytosol Biological process • apoptosis • cell aging • negative regulation of JUN kinase activity • negative regulation of cell cycle • negative regulation of transcription, DNA-dependent • negative regulation of transcription, DNA-dependent Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27250	18569
Ensembl	ENSG00000150593	ENSMUSG00000024975
UniProt	Q53EL6	n/a
RefSeq (mRNA)	NM_001199492.1	NM_011050
RefSeq (protein)	NP_001186421.1	NP_035180
Location (UCSC)	Chr 10: 112.63 – 112.66 Mb	Chr 19: 53.97 – 54 Mb
PubMed search	[1]	[2]

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.^[1][2] It is one of the targets of an oncomiR, MIRN21.^[3]

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.^[2]

Interactions

PDCD4 has been shown to interact with RPS13^[4] and Ribosomal protein L5.^[4]

References

1. ^ Azzoni, L; Zatsepina, O; Abebe, B; Bennett, IM; Kanakaraj, P; Perussia, B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of immunology 161 (7): 3493–500. PMID 9759869. 
2. ^ ^{a b} EntrezGene 27250
3. ^ Frankel, LB; Christoffersen, NR; Jacobsen, A; Lindow, M; Krogh, A; Lund, AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of biological chemistry 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735. 
4. ^ ^{a b} Kang, M; Ahn, HS; Lee, JY; Matsuhashi, S; Park, WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647. 

Further reading

• Göke, Rüdiger; Gregel, Cornelia; Göke, Alexandra; Arnold, Rudolf; Schmidt, Harald; Lankat-Buttgereit, Brigitte (2004). "Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells". Annals of the New York Academy of Sciences 1014: 220–1. doi:10.1196/annals.1294.024. PMID 15153438. 
• Kazuo, M; Sumio, S (1994). "Oligo-capping: A simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Shibahara, K; Asano, M; Ishida, Y; Aoki, T; Koike, T; Honjo, T (1995). "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death". Gene 166 (2): 297–301. doi:10.1016/0378-1119(95)00607-9. PMID 8543179. 
• Suzuki, Y; Yoshitomo-Nakagawa, K; Maruyama, K; Suyama, A; Sugano, S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Yoshinaga, Hidetoshi; Matsuhashi, Sachiko; Fujiyama, Chisato; Masaki, Zenjiro (1999). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody". Pathology International 49 (12): 1067–77. doi:10.1046/j.1440-1827.1999.00995.x. PMID 10632927. 
• Soejima, H.; Miyoshi, O.; Yoshinaga, H.; Masaki, Z.; Ozaki, I.; Kajiwara, S.; Niikawa, N.; Matsuhashi, S. et al. (1999). "Assignment<footref rid="foot01">¹</footref> of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization". Cytogenetic and Genome Research 87: 113–4. doi:10.1159/000015408. 
• Kang, M; Ahn, HS; Lee, JY; Matsuhashi, S; Park, WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647. 
• Mammalian Gene Collection Program Team* (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Chen, Yuan; Kn�Sel, Thomas; Kristiansen, Glen; Pietas, Agnieszka; Garber, Mitchell E; Matsuhashi, Sachiko; Ozaki, Iwata; Petersen, Iver (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis". The Journal of Pathology 200 (5): 640–6. doi:10.1002/path.1378. PMID 12898601. 
• Yang, H.-S.; Cho, M.-H.; Zakowicz, H.; Hegamyer, G.; Sonenberg, N.; Colburn, N. H. (2004). "A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A". Molecular and Cellular Biology 24 (9): 3894–906. doi:10.1128/MCB.24.9.3894-3906.2004. PMC 387765. PMID 15082783. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=387765. 
• Brill, Laurence M.; Salomon, Arthur R.; Ficarro, Scott B.; Mukherji, Mridul; Stettler-Gill, Michelle; Peters, Eric C. (2004). "Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry". Analytical Chemistry 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186. 
• Deloukas, P.; Earthrowl, M. E.; Grafham, D. V.; Rubenfield, M.; French, L.; Steward, C. A.; Sims, S. K.; Jones, M. C. et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054. 
• Goke, R. (2004). "Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1". AJP: Cell Physiology 287 (6): C1541–6. doi:10.1152/ajpcell.00025.2004. 
• Gerhard, DS; Wagner, L; Feingold, EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Research 14 (10b): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rush, John; Moritz, Albrecht; Lee, Kimberly A; Guo, Ailan; Goss, Valerie L; Spek, Erik J; Zhang, Hui; Zha, Xiang-Ming et al. (2004). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. 
• Rual, Jean-François; Venkatesan, Kavitha; Hao, Tong; Hirozane-Kishikawa, Tomoko; Dricot, Amélie; Li, Ning; Berriz, Gabriel F.; Gibbons, Francis D. et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Palamarchuk, A.; Efanov, A; Maximov, V; Aqeilan, RI; Croce, CM; Pekarsky, Y (2005). "Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein". Cancer Research 65 (24): 11282–6. doi:10.1158/0008-5472.CAN-05-3469. PMID 16357133. 
• Yang, H.-S.; Matthews, C. P.; Clair, T.; Wang, Q.; Baker, A. R.; Li, C.-C. H.; Tan, T.-H.; Colburn, N. H. (2006). "Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion". Molecular and Cellular Biology 26 (4): 1297–306. doi:10.1128/MCB.26.4.1297-1306.2006. PMC 1367180. PMID 16449643. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1367180.