RPLP1

Ribosomal protein, large, P1, also known as RPLP1, is a human gene.cite web | title = Entrez Gene: RPLP1 ribosomal protein, large, P1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6176| accessdate = ]

PBB_Summary
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summary_text = Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.cite web | title = Entrez Gene: RPLP1 ribosomal protein, large, P1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6176| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wool IG, Chan YL, Glück A |title=Structure and evolution of mammalian ribosomal proteins. |journal=Biochem. Cell Biol. |volume=73 |issue= 11-12 |pages= 933–47 |year= 1996 |pmid= 8722009 |doi=
*cite journal | author=Rich BE, Steitz JA |title=Human acidic ribosomal phosphoproteins P0, P1, and P2: analysis of cDNA clones, in vitro synthesis, and assembly. |journal=Mol. Cell. Biol. |volume=7 |issue= 11 |pages= 4065–74 |year= 1988 |pmid= 3323886 |doi=
*cite journal | author=Kato S, Sekine S, Oh SW, "et al." |title=Construction of a human full-length cDNA bank. |journal=Gene |volume=150 |issue= 2 |pages= 243–50 |year= 1995 |pmid= 7821789 |doi=
*cite journal | author=Tchórzewski M, Boldyreff B, Issinger O, Grankowski N |title=Analysis of the protein-protein interactions between the human acidic ribosomal P-proteins: evaluation by the two hybrid system. |journal=Int. J. Biochem. Cell Biol. |volume=32 |issue= 7 |pages= 737–46 |year= |pmid= 10856704 |doi=
*cite journal | author=Chan SH, Hung FS, Chan DS, Shaw PC |title=Trichosanthin interacts with acidic ribosomal proteins P0 and P1 and mitotic checkpoint protein MAD2B. |journal=Eur. J. Biochem. |volume=268 |issue= 7 |pages= 2107–12 |year= 2001 |pmid= 11277934 |doi=
*cite journal | author=Uechi T, Tanaka T, Kenmochi N |title=A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders. |journal=Genomics |volume=72 |issue= 3 |pages= 223–30 |year= 2001 |pmid= 11401437 |doi= 10.1006/geno.2000.6470
*cite journal | author=Yoshihama M, Uechi T, Asakawa S, "et al." |title=The human ribosomal protein genes: sequencing and comparative analysis of 73 genes. |journal=Genome Res. |volume=12 |issue= 3 |pages= 379–90 |year= 2002 |pmid= 11875025 |doi= 10.1101/gr.214202
*cite journal | author=Kang MJ, Ahn HS, Lee JY, "et al." |title=Up-regulation of PDCD4 in senescent human diploid fibroblasts. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 617–21 |year= 2002 |pmid= 12054647 |doi= 10.1016/S0006-291X(02)00264-4
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tchórzewski M, Krokowski D, Rzeski W, "et al." |title=The subcellular distribution of the human ribosomal "stalk" components: P1, P2 and P0 proteins. |journal=Int. J. Biochem. Cell Biol. |volume=35 |issue= 2 |pages= 203–11 |year= 2003 |pmid= 12479870 |doi=
*cite journal | author=Shu H, Chen S, Bi Q, "et al." |title=Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line. |journal=Mol. Cell Proteomics |volume=3 |issue= 3 |pages= 279–86 |year= 2004 |pmid= 14729942 |doi= 10.1074/mcp.D300003-MCP200
*cite journal | author=Giorgianni F, Beranova-Giorgianni S, Desiderio DM |title=Identification and characterization of phosphorylated proteins in the human pituitary. |journal=Proteomics |volume=4 |issue= 3 |pages= 587–98 |year= 2004 |pmid= 14997482 |doi= 10.1002/pmic.200300584
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Tao WA, Wollscheid B, O'Brien R, "et al." |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776
*cite journal | author=Gevaert K, Staes A, Van Damme J, "et al." |title=Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC. |journal=Proteomics |volume=5 |issue= 14 |pages= 3589–99 |year= 2006 |pmid= 16097034 |doi= 10.1002/pmic.200401217
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F |title=Phosphoproteomic analysis of the human pituitary. |journal=Pituitary |volume=9 |issue= 2 |pages= 109–20 |year= |pmid= 16807684 |doi= 10.1007/s11102-006-8916-x

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