TCF12

Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4), also known as TCF12, is a human gene.cite web | title = Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6938| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.cite web | title = Entrez Gene: TCF12 transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6938| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bain G, Murre C |title=The role of E-proteins in B- and T-lymphocyte development. |journal=Semin. Immunol. |volume=10 |issue= 2 |pages= 143–53 |year= 1998 |pmid= 9618760 |doi= 10.1006/smim.1998.0116
*cite journal | author=Hu JS, Olson EN, Kingston RE |title=HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors. |journal=Mol. Cell. Biol. |volume=12 |issue= 3 |pages= 1031–42 |year= 1992 |pmid= 1312219 |doi=
*cite journal | author=Zhang Y, Bina M |title=The nucleotide sequence of the human transcription factor HTF4a cDNA. |journal=DNA Seq. |volume=2 |issue= 6 |pages= 397–403 |year= 1992 |pmid= 1446075 |doi=
*cite journal | author=Zhang Y, Doyle K, Bina M |title=Interactions of HTF4 with E-box motifs in the long terminal repeat of human immunodeficiency virus type 1. |journal=J. Virol. |volume=66 |issue= 9 |pages= 5631–4 |year= 1992 |pmid= 1501295 |doi=
*cite journal | author=Sommer L, Hagenbüchle O, Wellauer PK, Strubin M |title=Nuclear targeting of the transcription factor PTF1 is mediated by a protein subunit that does not bind to the PTF1 cognate sequence. |journal=Cell |volume=67 |issue= 5 |pages= 987–94 |year= 1992 |pmid= 1720355 |doi=
*cite journal | author=Zhang Y, Babin J, Feldhaus AL, "et al." |title=HTF4: a new human helix-loop-helix protein. |journal=Nucleic Acids Res. |volume=19 |issue= 16 |pages= 4555 |year= 1991 |pmid= 1886779 |doi=
*cite journal | author=Zhang Y, Flejter WL, Barcroft CL, "et al." |title=Localization of the human HTF4 transcription factors 4 gene (TCF12) to chromosome 15q21. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 3-4 |pages= 235–8 |year= 1995 |pmid= 7842744 |doi=
*cite journal | author=Doyle K, Zhang Y, Baer R, Bina M |title=Distinguishable patterns of protein-DNA interactions involving complexes of basic helix-loop-helix proteins. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 12099–105 |year= 1994 |pmid= 8163514 |doi=
*cite journal | author=Langlands K, Yin X, Anand G, Prochownik EV |title=Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. |journal=J. Biol. Chem. |volume=272 |issue= 32 |pages= 19785–93 |year= 1997 |pmid= 9242638 |doi=
*cite journal | author=Goldfarb AN, Lewandowska K, Pennell CA |title=Identification of a highly conserved module in E proteins required for in vivo helix-loop-helix dimerization. |journal=J. Biol. Chem. |volume=273 |issue= 5 |pages= 2866–73 |year= 1998 |pmid= 9446597 |doi=
*cite journal | author=Massari ME, Rivera RR, Voland JR, "et al." |title=Characterization of ABF-1, a novel basic helix-loop-helix transcription factor expressed in activated B lymphocytes. |journal=Mol. Cell. Biol. |volume=18 |issue= 6 |pages= 3130–9 |year= 1998 |pmid= 9584154 |doi=
*cite journal | author=Adell T, Gómez-Cuadrado A, Skoudy A, "et al." |title=Role of the basic helix-loop-helix transcription factor p48 in the differentiation phenotype of exocrine pancreas cancer cells. |journal=Cell Growth Differ. |volume=11 |issue= 3 |pages= 137–47 |year= 2000 |pmid= 10768861 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Mandolesi G, Gargano S, Pennuto M, "et al." |title=NGF-dependent and tissue-specific transcription of vgf is regulated by a CREB-p300 and bHLH factor interaction. |journal=FEBS Lett. |volume=510 |issue= 1-2 |pages= 50–6 |year= 2002 |pmid= 11755530 |doi=
*cite journal | author=Knöfler M, Meinhardt G, Bauer S, "et al." |title=Human Hand1 basic helix-loop-helix (bHLH) protein: extra-embryonic expression pattern, interaction partners and identification of its transcriptional repressor domains. |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 641–51 |year= 2002 |pmid= 11802795 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tremblay M, Herblot S, Lecuyer E, Hoang T |title=Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL. |journal=J. Biol. Chem. |volume=278 |issue= 15 |pages= 12680–7 |year= 2003 |pmid= 12566462 |doi= 10.1074/jbc.M209870200

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