- STC1
Stanniocalcin 1, also known as STC1, is a human
gene .cite web | title = Entrez Gene: STC1 stanniocalcin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6781| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.cite web | title = Entrez Gene: STC1 stanniocalcin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6781| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Chang AC, Jellinek DA, Reddel RR |title=Mammalian stanniocalcins and cancer. |journal=Endocr. Relat. Cancer |volume=10 |issue= 3 |pages= 359–73 |year= 2004 |pmid= 14503913 |doi=
*cite journal | author=Liang P, Averboukh L, Keyomarsi K, "et al." |title=Differential display and cloning of messenger RNAs from human breast cancer versus mammary epithelial cells. |journal=Cancer Res. |volume=52 |issue= 24 |pages= 6966–8 |year= 1993 |pmid= 1458489 |doi=
*cite journal | author=Chang AC, Janosi J, Hulsbeek M, "et al." |title=A novel human cDNA highly homologous to the fish hormone stanniocalcin. |journal=Mol. Cell. Endocrinol. |volume=112 |issue= 2 |pages= 241–7 |year= 1996 |pmid= 7489828 |doi=
*cite journal | author=Wagner GF, Guiraudon CC, Milliken C, Copp DH |title=Immunological and biological evidence for a stanniocalcin-like hormone in human kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 6 |pages= 1871–5 |year= 1995 |pmid= 7892193 |doi=
*cite journal | author=Olsen HS, Cepeda MA, Zhang QQ, "et al." |title=Human stanniocalcin: a possible hormonal regulator of mineral metabolism. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 5 |pages= 1792–6 |year= 1996 |pmid= 8700837 |doi=
*cite journal | author=Chang AC, Jeffrey KJ, Tokutake Y, "et al." |title=Human stanniocalcin (STC): genomic structure, chromosomal localization, and the presence of CAG trinucleotide repeats. |journal=Genomics |volume=47 |issue= 3 |pages= 393–8 |year= 1998 |pmid= 9480753 |doi= 10.1006/geno.1997.5120
*cite journal | author=Zhang KZ, Westberg JA, Paetau A, "et al." |title=High expression of stanniocalcin in differentiated brain neurons. |journal=Am. J. Pathol. |volume=153 |issue= 2 |pages= 439–45 |year= 1998 |pmid= 9708804 |doi=
*cite journal | author=Varghese R, Wong CK, Deol H, "et al." |title=Comparative analysis of mammalian stanniocalcin genes. |journal=Endocrinology |volume=139 |issue= 11 |pages= 4714–25 |year= 1998 |pmid= 9794484 |doi=
*cite journal | author=Zhang K, Lindsberg PJ, Tatlisumak T, "et al." |title=Stanniocalcin: A molecular guard of neurons during cerebral ischemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3637–42 |year= 2000 |pmid= 10725397 |doi= 10.1073/pnas.070045897
*cite journal | author=Jellinek DA, Chang AC, Larsen MR, "et al." |title=Stanniocalcin 1 and 2 are secreted as phosphoproteins from human fibrosarcoma cells. |journal=Biochem. J. |volume=350 Pt 2 |issue= |pages= 453–61 |year= 2001 |pmid= 10947959 |doi=
*cite journal | author=Varghese R, Gagliardi AD, Bialek PE, "et al." |title=Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. |journal=Endocrinology |volume=143 |issue= 3 |pages= 868–76 |year= 2002 |pmid= 11861508 |doi=
*cite journal | author=McCudden CR, James KA, Hasilo C, Wagner GF |title=Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45249–58 |year= 2003 |pmid= 12223480 |doi= 10.1074/jbc.M205954200
*cite journal | author=Serlachius M, Alitalo R, Olsen HS, Andersson LC |title=Expression of stanniocalcin-1 in megakaryocytes and platelets. |journal=Br. J. Haematol. |volume=119 |issue= 2 |pages= 359–63 |year= 2002 |pmid= 12406069 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Sheikh-Hamad D, Bick R, Wu GY, "et al." |title=Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 1 |pages= H442–8 |year= 2003 |pmid= 12663264 |doi= 10.1152/ajpheart.01071.2002
*cite journal | author=Zlot C, Ingle G, Hongo J, "et al." |title=Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. |journal=J. Biol. Chem. |volume=278 |issue= 48 |pages= 47654–9 |year= 2004 |pmid= 14500721 |doi= 10.1074/jbc.M301353200
*cite journal | author=McCudden CR, Majewski A, Chakrabarti S, Wagner GF |title=Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas. |journal=Mol. Cell. Endocrinol. |volume=213 |issue= 2 |pages= 167–72 |year= 2004 |pmid= 15062564 |doi= 10.1016/j.mce.2003.10.042
*cite journal | author=Luo CW, Kawamura K, Klein C, Hsueh AJ |title=Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. |journal=Mol. Endocrinol. |volume=18 |issue= 8 |pages= 2085–96 |year= 2005 |pmid= 15131261 |doi= 10.1210/me.2004-0066
*cite journal | author=Serlachius M, Andersson LC |title=Upregulated expression of stanniocalcin-1 during adipogenesis. |journal=Exp. Cell Res. |volume=296 |issue= 2 |pages= 256–64 |year= 2004 |pmid= 15149855 |doi= 10.1016/j.yexcr.2004.02.016PBB_Controls
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