MAP1B

Microtubule-associated protein 1B, also known as MAP1B, is a human gene.cite web | title = Entrez Gene: MAP1B microtubule-associated protein 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4131| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system. Two alternatively spliced transcript variants have been described.cite web | title = Entrez Gene: MAP1B microtubule-associated protein 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hammarback JA, Obar RA, Hughes SM, Vallee RB |title=MAP1B is encoded as a polyprotein that is processed to form a complex N-terminal microtubule-binding domain. |journal=Neuron |volume=7 |issue= 1 |pages= 129–39 |year= 1991 |pmid= 1712602 |doi=
*cite journal | author=Lien LL, Boyce FM, Kleyn P, "et al." |title=Mapping of human microtubule-associated protein 1B in proximity to the spinal muscular atrophy locus at 5q13. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 17 |pages= 7873–6 |year= 1991 |pmid= 1881920 |doi=
*cite journal | author=Schoenfeld TA, McKerracher L, Obar R, Vallee RB |title=MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS. |journal=J. Neurosci. |volume=9 |issue= 5 |pages= 1712–30 |year= 1989 |pmid= 2470876 |doi=
*cite journal | author=Avila J, Ulloa L, Diez-Guerra J, Diaz-Nido J |title=Role of phosphorylated MAPlB in neuritogenesis. |journal=Cell Biol. Int. |volume=18 |issue= 5 |pages= 309–14 |year= 1994 |pmid= 7519512 |doi=
*cite journal | author=Lien LL, Feener CA, Fischbach N, Kunkel LM |title=Cloning of human microtubule-associated protein 1B and the identification of a related gene on chromosome 15. |journal=Genomics |volume=22 |issue= 2 |pages= 273–80 |year= 1995 |pmid= 7806212 |doi= 10.1006/geno.1994.1384
*cite journal | author=Ohyu J, Takashima S |title=Decreased expression of microtubule-associated protein 5 (MAP5) in the molecular layer of cerebellum in preterm infants with olivocerebellar lesions. |journal=Brain Dev. |volume=20 |issue= 1 |pages= 22–6 |year= 1998 |pmid= 9533556 |doi=
*cite journal | author=Lucas FR, Goold RG, Gordon-Weeks PR, Salinas PC |title=Inhibition of GSK-3beta leading to the loss of phosphorylated MAP-1B is an early event in axonal remodelling induced by WNT-7a or lithium. |journal=J. Cell. Sci. |volume=111 ( Pt 10) |issue= |pages= 1351–61 |year= 1998 |pmid= 9570753 |doi=
*cite journal | author=Tögel M, Wiche G, Propst F |title=Novel features of the light chain of microtubule-associated protein MAP1B: microtubule stabilization, self interaction, actin filament binding, and regulation by the heavy chain. |journal=J. Cell Biol. |volume=143 |issue= 3 |pages= 695–707 |year= 1998 |pmid= 9813091 |doi=
*cite journal | author=Hanley JG, Koulen P, Bedford F, "et al." |title=The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. |journal=Nature |volume=397 |issue= 6714 |pages= 66–9 |year= 1999 |pmid= 9892354 |doi= 10.1038/16258
*cite journal | author=Jensen PH, Islam K, Kenney J, "et al." |title=Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21500–7 |year= 2000 |pmid= 10764738 |doi= 10.1074/jbc.M000099200
*cite journal | author=Tanner SL, Franzen R, Jaffe H, Quarles RH |title=Evidence for expression of some microtubule-associated protein 1B in neurons as a plasma membrane glycoprotein. |journal=J. Neurochem. |volume=75 |issue= 2 |pages= 553–62 |year= 2000 |pmid= 10899930 |doi=
*cite journal | author=Mei X, Sweatt AJ, Hammarback JA |title=Regulation of microtubule-associated protein 1B (MAP1B) subunit composition. |journal=J. Neurosci. Res. |volume=62 |issue= 1 |pages= 56–64 |year= 2000 |pmid= 11002287 |doi=
*cite journal | author=Billups D, Hanley JG, Orme M, "et al." |title=GABAC receptor sensitivity is modulated by interaction with MAP1B. |journal=J. Neurosci. |volume=20 |issue= 23 |pages= 8643–50 |year= 2001 |pmid= 11102469 |doi=
*cite journal | author=Franzen R, Tanner SL, Dashiell SM, "et al." |title=Microtubule-associated protein 1B: a neuronal binding partner for myelin-associated glycoprotein. |journal=J. Cell Biol. |volume=155 |issue= 6 |pages= 893–8 |year= 2002 |pmid= 11733546 |doi= 10.1083/jcb.200108137
*cite journal | author=Ding J, Liu JJ, Kowal AS, "et al." |title=Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin. |journal=J. Cell Biol. |volume=158 |issue= 3 |pages= 427–33 |year= 2002 |pmid= 12147674 |doi= 10.1083/jcb.200202055
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dergunova LV, Raevskaya NM, Vladychenskaya IP, Limborska SA |title=Hmob3 brain-specific sequence is a part of phylogenetically conserved human MAP1B gene 3'-untranslated region. |journal=Biomol. Eng. |volume=20 |issue= 3 |pages= 91–6 |year= 2004 |pmid= 12684070 |doi=
*cite journal | author=Chang L, Jones Y, Ellisman MH, "et al." |title=JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. |journal=Dev. Cell |volume=4 |issue= 4 |pages= 521–33 |year= 2003 |pmid= 12689591 |doi=
*cite journal | author=Opal P, Garcia JJ, Propst F, "et al." |title=Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34691–9 |year= 2003 |pmid= 12807913 |doi= 10.1074/jbc.M302785200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285

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