GABRR1

Gamma-aminobutyric acid (GABA) receptor, rho 1, also known as GABRR1, is a human gene.cite web | title = Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2569| accessdate = ]

PBB_Summary
section_title =
summary_text = GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family.cite web | title = Entrez Gene: GABRR1 gamma-aminobutyric acid (GABA) receptor, rho 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2569| accessdate = ]

ee also

* GABAC receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cutting GR, Curristin S, Zoghbi H, "et al." |title=Identification of a putative gamma-aminobutyric acid (GABA) receptor subunit rho2 cDNA and colocalization of the genes encoding rho2 (GABRR2) and rho1 (GABRR1) to human chromosome 6q14-q21 and mouse chromosome 4. |journal=Genomics |volume=12 |issue= 4 |pages= 801–6 |year= 1992 |pmid= 1315307 |doi=
*cite journal | author=Cutting GR, Lu L, O'Hara BF, "et al." |title=Cloning of the gamma-aminobutyric acid (GABA) rho 1 cDNA: a GABA receptor subunit highly expressed in the retina. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2673–7 |year= 1991 |pmid= 1849271 |doi=
*cite journal | author=Wang TL, Hackam A, Guggino WB, Cutting GR |title=A single histidine residue is essential for zinc inhibition of GABA rho 1 receptors. |journal=J. Neurosci. |volume=15 |issue= 11 |pages= 7684–91 |year= 1995 |pmid= 7472519 |doi=
*cite journal | author=Hackam AS, Wang TL, Guggino WB, Cutting GR |title=The N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interaction. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13750–7 |year= 1997 |pmid= 9153229 |doi=
*cite journal | author=Kusama T, Hatama K, Sakurai M, "et al." |title=Consensus phosphorylation sites of human GABA(c)/GABArho receptors are not critical for inhibition by protein kinase C activation. |journal=Neurosci. Lett. |volume=255 |issue= 1 |pages= 17–20 |year= 1999 |pmid= 9839716 |doi=
*cite journal | author=Hanley JG, Koulen P, Bedford F, "et al." |title=The protein MAP-1B links GABA(C) receptors to the cytoskeleton at retinal synapses. |journal=Nature |volume=397 |issue= 6714 |pages= 66–9 |year= 1999 |pmid= 9892354 |doi= 10.1038/16258
*cite journal | author=Bailey ME, Albrecht BE, Johnson KJ, Darlison MG |title=Genetic linkage and radiation hybrid mapping of the three human GABA(C) receptor rho subunit genes: GABRR1, GABRR2 and GABRR3. |journal=Biochim. Biophys. Acta |volume=1447 |issue= 2-3 |pages= 307–12 |year= 1999 |pmid= 10542332 |doi=
*cite journal | author=Hanley JG, Jones EM, Moss SJ |title=GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. |journal=J. Biol. Chem. |volume=275 |issue= 2 |pages= 840–6 |year= 2000 |pmid= 10625616 |doi=
*cite journal | author=Filippova N, Sedelnikova A, Zong Y, "et al." |title=Regulation of recombinant gamma-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. |journal=Mol. Pharmacol. |volume=57 |issue= 5 |pages= 847–56 |year= 2000 |pmid= 10779366 |doi=
*cite journal | author=Billups D, Hanley JG, Orme M, "et al." |title=GABAC receptor sensitivity is modulated by interaction with MAP1B. |journal=J. Neurosci. |volume=20 |issue= 23 |pages= 8643–50 |year= 2001 |pmid= 11102469 |doi=
*cite journal | author=Wang QW, Li ZW, Wang F, Yang JQ |title=Modulation by divalent cations of GABA rho 1 receptor from human retina expressed in Xenopus oocytes. |journal=Biomed. Environ. Sci. |volume=14 |issue= 4 |pages= 269–77 |year= 2002 |pmid= 11862606 |doi=
*cite journal | author=Sedelnikova A, Weiss DS |title=Phosphorylation of the recombinant rho1 GABA receptor. |journal=Int. J. Dev. Neurosci. |volume=20 |issue= 3-5 |pages= 237–46 |year= 2002 |pmid= 12175859 |doi=
*cite journal | author=Torres VI, Weiss DS |title=Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous opening. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 43741–8 |year= 2003 |pmid= 12226075 |doi= 10.1074/jbc.M202007200
*cite journal | author=Croci C, Brändstatter JH, Enz R |title=ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6128–35 |year= 2003 |pmid= 12431995 |doi= 10.1074/jbc.M205162200
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Boué-Grabot E, Emerit MB, Toulmé E, "et al." |title=Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6967–75 |year= 2004 |pmid= 14660627 |doi= 10.1074/jbc.M307772200
*cite journal | author=Martínez-Torres A, Miledi R |title=A single amino acid change within the ion-channel domain of the gamma-aminobutyric acid rho1 receptor accelerates desensitization and increases taurine agonism. |journal=Arch. Med. Res. |volume=35 |issue= 3 |pages= 194–8 |year= 2004 |pmid= 15163459 |doi= 10.1016/j.arcmed.2003.12.002
*cite journal | author=Sedelnikova A, Smith CD, Zakharkin SO, "et al." |title=Mapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete model. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1535–42 |year= 2005 |pmid= 15548535 |doi= 10.1074/jbc.M409908200
*cite journal | author=Song XQ, Meng F, Ramsey DJ, "et al." |title=The GABA rho1 subunit interacts with a cellular retinoic acid binding protein in mammalian retina. |journal=Neuroscience |volume=136 |issue= 2 |pages= 467–75 |year= 2006 |pmid= 16198491 |doi= 10.1016/j.neuroscience.2005.08.018

External links

*

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