DPYSL2

Dihydropyrimidinase-like 2
PDB rendering based on 2gse.
Available structures PDB 2GSE, 2VM8
Identifiers
Symbols	DPYSL2; CRMP2; DHPRP2; DRP-2; DRP2
External IDs	OMIM: 602463 MGI: 1349763 HomoloGene: 74392 GeneCards: DPYSL2 Gene
Gene Ontology Molecular function • dihydropyrimidinase activity • protein binding Cellular component • soluble fraction • cytoplasm • mitochondrion • cytosol • cytosol • synaptosome • axon • dendrite • growth cone • neuronal cell body • terminal button • protein complex Biological process • response to amphetamine • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process • pyrimidine base catabolic process • signal transduction • multicellular organismal development • nervous system development • axon guidance • brain development • positive regulation of glutamate secretion • spinal cord development • olfactory bulb development • cell differentiation • response to cocaine • response to drug • regulation of neuron differentiation • synaptic vesicle transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1808	12934
Ensembl	ENSG00000092964	ENSMUSG00000022048
UniProt	Q16555	O08553
RefSeq (mRNA)	NM_001197293.1	NM_009955.3
RefSeq (protein)	NP_001184222.1	NP_034085.2
Location (UCSC)	Chr 8: 26.37 – 26.52 Mb	Chr 14: 67.42 – 67.49 Mb
PubMed search	[1]	[2]

Dihydropyrimidinase-related protein 2 is an enzyme that in humans is encoded by the DPYSL2 gene.^[1][2]

Interactions

DPYSL2 has been shown to interact with CRMP1,^[3] Adaptor-related protein complex 2, alpha 1^[4] and NUMB.^[4]

References

1. ^ Hamajima N, Matsuda K, Sakata S, Tamaki N, Sasaki M, Nonaka M (Jan 1997). "A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution". Gene 180 (1–2): 157–63. doi:10.1016/S0378-1119(96)00445-3. PMID 8973361. 
2. ^ "Entrez Gene: DPYSL2 dihydropyrimidinase-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1808. 
3. ^ Leung, Thomas; Ng Yvonne, Cheong Albert, Ng Chong Han, Tan Ivan, Hall Christine, Lim Louis (Dec. 2002). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. (Netherlands) 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. ISSN 0014-5793. PMID 12482610. 
4. ^ ^{a b} Nishimura, Takashi; Fukata Yuko, Kato Katsuhiro, Yamaguchi Tomoya, Matsuura Yoshiharu, Kamiguchi Hiroyuki, Kaibuchi Kozo (Sep. 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. (England) 5 (9): 819–26. doi:10.1038/ncb1039. ISSN 1465-7392. PMID 12942088. 

Further reading

• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151. 
• Goshima Y, Nakamura F, Strittmatter P, Strittmatter SM (1995). "Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33". Nature 376 (6540): 509–14. doi:10.1038/376509a0. PMID 7637782. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Roberts RG, Freeman TC, Kendall E, et al. (1996). "Characterization of DRP2, a novel human dystrophin homologue". Nat. Genet. 13 (2): 223–6. doi:10.1038/ng0696-223. PMID 8640231. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Kitamura K, Takayama M, Hamajima N, et al. (2000). "Characterization of the human dihydropyrimidinase-related protein 2 (DRP-2) gene". DNA Res. 6 (5): 291–7. doi:10.1093/dnares/6.5.291. PMID 10574455. 
• Gu Y, Hamajima N, Ihara Y (2000). "Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522". Biochemistry 39 (15): 4267–75. doi:10.1021/bi992323h. PMID 10757975. 
• Gu Y, Ihara Y (2000). "Evidence that collapsin response mediator protein-2 is involved in the dynamics of microtubules". J. Biol. Chem. 275 (24): 17917–20. doi:10.1074/jbc.C000179200. PMID 10770920. 
• Arimura N, Inagaki N, Chihara K, et al. (2000). "Phosphorylation of collapsin response mediator protein-2 by Rho-kinase. Evidence for two separate signaling pathways for growth cone collapse". J. Biol. Chem. 275 (31): 23973–80. doi:10.1074/jbc.M001032200. PMID 10818093. 
• Fukada M, Watakabe I, Yuasa-Kawada J, et al. (2001). "Molecular characterization of CRMP5, a novel member of the collapsin response mediator protein family". J. Biol. Chem. 275 (48): 37957–65. doi:10.1074/jbc.M003277200. PMID 10956643. 
• Santolini E, Puri C, Salcini AE, et al. (2001). "Numb Is an Endocytic Protein". J. Cell Biol. 151 (6): 1345–52. doi:10.1083/jcb.151.6.1345. PMC 2190585. PMID 11121447. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2190585. 
• Lee S, Kim JH, Lee CS, et al. (2002). "Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction". J. Biol. Chem. 277 (8): 6542–9. doi:10.1074/jbc.M108047200. PMID 11741937. 
• Weitzdoerfer R, Fountoulakis M, Lubec G (2002). "Aberrant expression of dihydropyrimidinase related proteins-2,-3 and -4 in fetal Down syndrome brain". J. Neural Transm. Suppl. (61): 95–107. PMID 11771764. 
• Fukata Y, Itoh TJ, Kimura T, et al. (2002). "CRMP-2 binds to tubulin heterodimers to promote microtubule assembly". Nat. Cell Biol. 4 (8): 583–91. doi:10.1038/ncb825. PMID 12134159. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Leung T, Ng Y, Cheong A, et al. (2003). "p80 ROKalpha binding protein is a novel splice variant of CRMP-1 which associates with CRMP-2 and modulates RhoA-induced neuronal morphology". FEBS Lett. 532 (3): 445–9. doi:10.1016/S0014-5793(02)03736-5. PMID 12482610. 
• Nishimura T, Fukata Y, Kato K, et al. (2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. 5 (9): 819–26. doi:10.1038/ncb1039. PMID 12942088. 
• Nakata K, Ujike H, Tanaka Y, et al. (2003). "No association between the dihydropyrimidinase-related protein 2 (DRP-2) gene and bipolar disorder in humans". Neurosci. Lett. 349 (3): 171–4. doi:10.1016/S0304-3940(03)00824-3. PMID 12951196. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.