TNFSF12

Tumor necrosis factor (ligand) superfamily, member 12, also known as TNFSF12, is a human gene.cite web | title = Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8742| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis.cite web | title = Entrez Gene: TNFSF12 tumor necrosis factor (ligand) superfamily, member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8742| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wiley SR, Winkles JA |title=TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor. |journal=Cytokine Growth Factor Rev. |volume=14 |issue= 3-4 |pages= 241–9 |year= 2004 |pmid= 12787562 |doi=
*cite journal | author=Campbell S, Michaelson J, Burkly L, Putterman C |title=The role of TWEAK/Fn14 in the pathogenesis of inflammation and systemic autoimmunity. |journal=Front. Biosci. |volume=9 |issue= |pages= 2273–84 |year= 2006 |pmid= 15353286 |doi=
*cite journal | author=Chicheportiche Y, Bourdon PR, Xu H, "et al." |title=TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. |journal=J. Biol. Chem. |volume=272 |issue= 51 |pages= 32401–10 |year= 1998 |pmid= 9405449 |doi=
*cite journal | author=Marsters SA, Sheridan JP, Pitti RM, "et al." |title=Identification of a ligand for the death-domain-containing receptor Apo3. |journal=Curr. Biol. |volume=8 |issue= 9 |pages= 525–8 |year= 1998 |pmid= 9560343 |doi=
*cite journal | author=Lynch CN, Wang YC, Lund JK, "et al." |title=TWEAK induces angiogenesis and proliferation of endothelial cells. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8455–9 |year= 1999 |pmid= 10085077 |doi=
*cite journal | author=Kaplan MJ, Ray D, Mo RR, "et al." |title=TRAIL (Apo2 ligand) and TWEAK (Apo3 ligand) mediate CD4+ T cell killing of antigen-presenting macrophages. |journal=J. Immunol. |volume=164 |issue= 6 |pages= 2897–904 |year= 2000 |pmid= 10706675 |doi=
*cite journal | author=Kaptein A, Jansen M, Dilaver G, "et al." |title=Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). |journal=FEBS Lett. |volume=485 |issue= 2-3 |pages= 135–41 |year= 2000 |pmid= 11094155 |doi=
*cite journal | author=Wiley SR, Cassiano L, Lofton T, "et al." |title=A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis. |journal=Immunity |volume=15 |issue= 5 |pages= 837–46 |year= 2001 |pmid= 11728344 |doi=
*cite journal | author=Nakayama M, Ishidoh K, Kayagaki N, "et al." |title=Multiple pathways of TWEAK-induced cell death. |journal=J. Immunol. |volume=168 |issue= 2 |pages= 734–43 |year= 2002 |pmid= 11777967 |doi=
*cite journal | author=Jakubowski A, Browning B, Lukashev M, "et al." |title=Dual role for TWEAK in angiogenic regulation. |journal=J. Cell. Sci. |volume=115 |issue= Pt 2 |pages= 267–74 |year= 2002 |pmid= 11839778 |doi=
*cite journal | author=Kaplan MJ, Lewis EE, Shelden EA, "et al." |title=The apoptotic ligands TRAIL, TWEAK, and Fas ligand mediate monocyte death induced by autologous lupus T cells. |journal=J. Immunol. |volume=169 |issue= 10 |pages= 6020–9 |year= 2003 |pmid= 12421989 |doi=
*cite journal | author=Harada N, Nakayama M, Nakano H, "et al." |title=Pro-inflammatory effect of TWEAK/Fn14 interaction on human umbilical vein endothelial cells. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 488–93 |year= 2003 |pmid= 12445828 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nakayama M, Ishidoh K, Kojima Y, "et al." |title=Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. |journal=J. Immunol. |volume=170 |issue= 1 |pages= 341–8 |year= 2003 |pmid= 12496418 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Tian XL, Kadaba R, You SA, "et al." |title=Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. |journal=Nature |volume=427 |issue= 6975 |pages= 640–5 |year= 2004 |pmid= 14961121 |doi= 10.1038/nature02320
*cite journal | author=Kim SH, Kang YJ, Kim WJ, "et al." |title=TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages. |journal=Circ. J. |volume=68 |issue= 4 |pages= 396–9 |year= 2004 |pmid= 15056843 |doi=
*cite journal | author=Jin L, Nakao A, Nakayama M, "et al." |title=Induction of RANTES by TWEAK/Fn14 interaction in human keratinocytes. |journal=J. Invest. Dermatol. |volume=122 |issue= 5 |pages= 1175–9 |year= 2004 |pmid= 15140220 |doi= 10.1111/j.0022-202X.2004.22419.x

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