TNFSF12-TNFSF13

Tumor necrosis factor (ligand) superfamily, member 12-member 13, also known as TNFSF12-TNFSF13, is a human gene.cite web | title = Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=407977| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the tumor necrosis factor superfamily (TNFSF). It encodes a hybrid protein composed of the cytoplasmic and transmembrane domains of the family member 12 fused to the C-terminal domain of the family member 13. The hybrid protein is membrane anchored and presents the receptor-binding domain of the family member 13 at the cell surface. It stimulates cycling in T- and B-lymphoma cell lines. The mRNA transcript is expressed and translated in primary T cells and monocytes.cite web | title = Entrez Gene: TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=407977| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hahne M, Kataoka T, Schröter M, "et al." |title=APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. |journal=J. Exp. Med. |volume=188 |issue= 6 |pages= 1185–90 |year= 1998 |pmid= 9743536 |doi=
*cite journal | author=Kelly K, Manos E, Jensen G, "et al." |title=APRIL/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. |journal=Cancer Res. |volume=60 |issue= 4 |pages= 1021–7 |year= 2000 |pmid= 10706119 |doi=
*cite journal | author=Wu Y, Bressette D, Carrell JA, "et al." |title=Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35478–85 |year= 2001 |pmid= 10956646 |doi= 10.1074/jbc.M005224200
*cite journal | author=Yu G, Boone T, Delaney J, "et al." |title=APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. |journal=Nat. Immunol. |volume=1 |issue= 3 |pages= 252–6 |year= 2001 |pmid= 10973284 |doi= 10.1038/79802
*cite journal | author=Gallouzi IE, Brennan CM, Steitz JA |title=Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. |journal=RNA |volume=7 |issue= 9 |pages= 1348–61 |year= 2001 |pmid= 11565755 |doi=
*cite journal | author=López-Fraga M, Fernández R, Albar JP, Hahne M |title=Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. |journal=EMBO Rep. |volume=2 |issue= 10 |pages= 945–51 |year= 2002 |pmid= 11571266 |doi= 10.1093/embo-reports/kve198
*cite journal | author=Roschke V, Sosnovtseva S, Ward CD, "et al." |title=BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. |journal=J. Immunol. |volume=169 |issue= 8 |pages= 4314–21 |year= 2002 |pmid= 12370363 |doi=
*cite journal | author=Pradet-Balade B, Medema JP, López-Fraga M, "et al." |title=An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion protein. |journal=EMBO J. |volume=21 |issue= 21 |pages= 5711–20 |year= 2002 |pmid= 12411489 |doi=
*cite journal | author=Hendriks J, Planelles L, de Jong-Odding J, "et al." |title=Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation. |journal=Cell Death Differ. |volume=12 |issue= 6 |pages= 637–48 |year= 2005 |pmid= 15846369 |doi= 10.1038/sj.cdd.4401647

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