PLA2G6

Phospholipase A2, group VI (cytosolic, calcium-independent), also known as PLA2G6, is a human gene.cite web | title = Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8398| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.cite web | title = Entrez Gene: PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8398| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schröder HC, Perovic S, Kavsan V, "et al." |title=Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. |journal=Neurotoxicology |volume=19 |issue= 4-5 |pages= 683–8 |year= 1998 |pmid= 9745929 |doi=
*cite journal | author=Leslie CC |title=Regulation of arachidonic acid availability for eicosanoid production. |journal=Biochem. Cell Biol. |volume=82 |issue= 1 |pages= 1–17 |year= 2004 |pmid= 15052324 |doi= 10.1139/o03-080
*cite journal | author=Turk J, Ramanadham S |title=The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells. |journal=Can. J. Physiol. Pharmacol. |volume=82 |issue= 10 |pages= 824–32 |year= 2005 |pmid= 15573142 |doi= 10.1139/y04-064
*cite journal | author=Law MH, Cotton RG, Berger GE |title=The role of phospholipases A2 in schizophrenia. |journal=Mol. Psychiatry |volume=11 |issue= 6 |pages= 547–56 |year= 2006 |pmid= 16585943 |doi= 10.1038/sj.mp.4001819
*cite journal | author=Tang J, Kriz RW, Wolfman N, "et al." |title=A novel cytosolic calcium-independent phospholipase A2 contains eight ankyrin motifs. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8567–75 |year= 1997 |pmid= 9079687 |doi=
*cite journal | author=Mavoungou E, Georges-Courbot MC, Poaty-Mavoungou V, "et al." |title=HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=16 |issue= 1 |pages= 1–9 |year= 1997 |pmid= 9377118 |doi=
*cite journal | author=Larsson PK, Claesson HE, Kennedy BP |title=Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity. |journal=J. Biol. Chem. |volume=273 |issue= 1 |pages= 207–14 |year= 1998 |pmid= 9417066 |doi=
*cite journal | author=Ma Z, Wang X, Nowatzke W, "et al." |title=Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1. |journal=J. Biol. Chem. |volume=274 |issue= 14 |pages= 9607–16 |year= 1999 |pmid= 10092647 |doi=
*cite journal | author=Larsson Forsell PK, Kennedy BP, Claesson HE |title=The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene. |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 575–85 |year= 1999 |pmid= 10336645 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Kim SJ, Gershov D, Ma X, "et al." |title=I-PLA(2) activation during apoptosis promotes the exposure of membrane lysophosphatidylcholine leading to binding by natural immunoglobulin M antibodies and complement activation. |journal=J. Exp. Med. |volume=196 |issue= 5 |pages= 655–65 |year= 2002 |pmid= 12208880 |doi=
*cite journal | author=Hichami A, Joshi B, Simonin AM, Khan NA |title=Role of three isoforms of phospholipase A2 in capacitative calcium influx in human T-cells. |journal=Eur. J. Biochem. |volume=269 |issue= 22 |pages= 5557–63 |year= 2003 |pmid= 12423354 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cummings BS, McHowat J, Schnellmann RG |title=Role of an endoplasmic reticulum Ca2+-independent phospholipase A2 in cisplatin-induced renal cell apoptosis. |journal=J. Pharmacol. Exp. Ther. |volume=308 |issue= 3 |pages= 921–8 |year= 2004 |pmid= 14634037 |doi= 10.1124/jpet.103.060541
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bao S, Jin C, Zhang S, "et al." |title=Beta-cell calcium-independent group VIA phospholipase A(2) (iPLA(2)beta): tracking iPLA(2)beta movements in response to stimulation with insulin secretagogues in INS-1 cells. |journal=Diabetes |volume=53 Suppl 1 |issue= |pages= S186–9 |year= 2004 |pmid= 14749286 |doi=
*cite journal | author=Tay HK, Melendez AJ |title=Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22505–13 |year= 2004 |pmid= 15007079 |doi= 10.1074/jbc.M308788200
*cite journal | author=Tanaka H, Minakami R, Kanaya H, Sumimoto H |title=Catalytic residues of group VIB calcium-independent phospholipase A2 (iPLA2gamma). |journal=Biochem. Biophys. Res. Commun. |volume=320 |issue= 4 |pages= 1284–90 |year= 2004 |pmid= 15249229 |doi= 10.1016/j.bbrc.2004.05.225

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