Metallothionein 1A

Metallothionein 1A
PDB rendering based on 1mhu.
Available structures PDB 1mhu, 1mrb, 2mhu
Identifiers
Symbols	MT1A; MGC32848; MT1; MT1S; MTC
External IDs	OMIM: 156350 HomoloGene: 88733 GeneCards: MT1A Gene
Gene Ontology Molecular function • copper ion binding • zinc ion binding • cadmium ion binding • metal ion binding Cellular component • cytoplasm Biological process • biological_process Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4489	n/a
Ensembl	ENSG00000205362	n/a
UniProt	P04731	n/a
RefSeq (mRNA)	NM_005946	n/a
RefSeq (protein)	NP_005937	n/a
Location (UCSC)	Chr 16: 56.67 – 56.67 Mb	n/a
PubMed search	[1]	n/a

Metallothionein-1A is a protein that in humans is encoded by the MT1A gene.^[1][2][3]

References

1. ^ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A 81 (17): 5494–8. doi:10.1073/pnas.81.17.5494. PMC 391732. PMID 6089206. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=391732. 
2. ^ Richards RI, Heguy A, Karin M (Jun 1984). "Structural and functional analysis of the human metallothionein-IA gene: differential induction by metal ions and glucocorticoids". Cell 37 (1): 263–72. doi:10.1016/0092-8674(84)90322-2. PMID 6327055. 
3. ^ "Entrez Gene: MT1A metallothionein 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4489. 

Further reading

• Thirumoorthy N, Manisenthil Kumar KT, Shyam Sundar A, et al. (2007). "Metallothionein: an overview.". World J. Gastroenterol. 13 (7): 993–6. PMID 17373731. 
• Sutherland GR, Baker E, Callen DF, et al. (1990). "The human metallothionein gene cluster is not disrupted in myelomonocytic leukemia.". Genomics 6 (1): 144–8. doi:10.1016/0888-7543(90)90459-8. PMID 2303255. 
• Grider A, Bailey LB, Cousins RJ (1990). "Erythrocyte metallothionein as an index of zinc status in humans.". Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1259–62. doi:10.1073/pnas.87.4.1259. PMC 53453. PMID 2304897. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=53453. 
• Le Beau MM, Diaz MO, Karin M, Rowley JD (1985). "Metallothionein gene cluster is split by chromosome 16 rearrangements in myelomonocytic leukaemia.". Nature 313 (6004): 709–11. doi:10.1038/313709a0. PMID 3856101. 
• Hunziker PE, Kägi JH (1985). "Isolation and characterization of six human hepatic isometallothioneins.". Biochem. J. 231 (2): 375–82. PMC 1152756. PMID 4062903. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1152756. 
• Armitage IM, Otvos JD, Briggs RW, Boulanger Y (1983). "Structure elucidation of the metal-binding sites in metallothionein by 113Cd NMR.". Fed. Proc. 41 (13): 2974–80. PMID 7140998. 
• Akintola DF, Sampson B, Fleck A (1995). "Development of an enzyme-linked immunosorbent assay for human metallothionein-1 in plasma and urine.". J. Lab. Clin. Med. 126 (2): 119–27. PMID 7543551. 
• Davis SR, McMahon RJ, Cousins RJ (1998). "Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression.". J. Nutr. 128 (5): 825–31. PMID 9566988. 
• Simpkins C, Lloyd T, Li S, Balderman S (1998). "Metallothionein-induced increase in mitochondrial inner membrane permeability.". J. Surg. Res. 75 (1): 30–4. doi:10.1006/jsre.1997.5241. PMID 9614853. 
• Lau JC, Cherian MG (1999). "Developmental changes in hepatic metallothionein, zinc, and copper levels in genetically altered mice.". Biochem. Cell Biol. 76 (4): 615–23. doi:10.1139/bcb-76-4-615. PMID 10099782. 
• Levadoux M, Mahon C, Beattie JH, et al. (2000). "Nuclear import of metallothionein requires its mRNA to be associated with the perinuclear cytoskeleton.". J. Biol. Chem. 274 (49): 34961–6. doi:10.1074/jbc.274.49.34961. PMID 10574972. 
• Garrett SH, Sens MA, Shukla D, et al. (2000). "Metallothionein isoform 1 and 2 gene expression in the human prostate: downregulation of MT-1X in advanced prostate cancer.". Prostate 43 (2): 125–35. doi:10.1002/(SICI)1097-0045(20000501)43:2<125::AID-PROS7>3.0.CO;2-S. PMID 10754528. 
• Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes.". Cell. Mol. Biol. (Noisy-le-grand) 46 (2): 419–33. PMID 10774930. 
• Campagne MV, Thibodeaux H, van Bruggen N, et al. (2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion.". J. Neurosci. 20 (14): 5200–7. PMID 10884303. 
• Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood.". Eur. J. Biochem. 268 (3): 849–56. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427. 
• Levadoux-Martin M, Hesketh JE, Beattie JH, Wallace HM (2001). "Influence of metallothionein-1 localization on its function.". Biochem. J. 355 (Pt 2): 473–9. doi:10.1042/0264-6021:3550473. PMC 1221760. PMID 11284736. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221760. 
• Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with special emphasis on metallothioneins.". Analytical and bioanalytical chemistry 372 (3): 412–7. doi:10.1007/s00216-001-1187-5. PMID 11939525. 
• Minami T, Kubo K, Ichida S (2003). "Determination of metallothionein-1/metallothionein-2 ratios in the mouse liver and pancreas by capillary zone electrophoresis using a polyacrylamide-coated capillary at neutral pH.". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 779 (2): 211–9. PMID 12361735.