LMAN1

Lectin, mannose-binding, 1, also known as LMAN1, is a human gene.cite web | title = Entrez Gene: LMAN1 lectin, mannose-binding, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3998| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi, presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning, the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency, a rare, autosomal recessive disorder in which both coagulation factors V and VIII are diminished.cite web | title = Entrez Gene: LMAN1 lectin, mannose-binding, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3998| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Botos I, Wlodawer A |title=Proteins that bind high-mannose sugars of the HIV envelope. |journal=Prog. Biophys. Mol. Biol. |volume=88 |issue= 2 |pages= 233–82 |year= 2005 |pmid= 15572157 |doi= 10.1016/j.pbiomolbio.2004.05.001
*cite journal | author=Arar C, Carpentier V, Le Caer JP, "et al." |title=ERGIC-53, a membrane protein of the endoplasmic reticulum-Golgi intermediate compartment, is identical to MR60, an intracellular mannose-specific lectin of myelomonocytic cells. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3551–3 |year= 1995 |pmid= 7876089 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Fiedler K, Simons K |title=A putative novel class of animal lectins in the secretory pathway homologous to leguminous lectins. |journal=Cell |volume=77 |issue= 5 |pages= 625–6 |year= 1994 |pmid= 8205612 |doi=
*cite journal | author=Schindler R, Itin C, Zerial M, "et al." |title=ERGIC-53, a membrane protein of the ER-Golgi intermediate compartment, carries an ER retention motif. |journal=Eur. J. Cell Biol. |volume=61 |issue= 1 |pages= 1–9 |year= 1993 |pmid= 8223692 |doi=
*cite journal | author=Haurum JS, Thiel S, Jones IM, "et al." |title=Complement activation upon binding of mannan-binding protein to HIV envelope glycoproteins. |journal=AIDS |volume=7 |issue= 10 |pages= 1307–13 |year= 1994 |pmid= 8267903 |doi=
*cite journal | author=Senaldi G, Davies ET, Mahalingam M, "et al." |title=Circulating levels of mannose binding protein in human immunodeficiency virus infection. |journal=J. Infect. |volume=31 |issue= 2 |pages= 145–8 |year= 1996 |pmid= 8666845 |doi=
*cite journal | author=Arar C, Mignon C, Mattei M, "et al." |title=Mapping of the MR60/ERGIC-53 gene to human chromosome 18q21.3-18q22 by in situ hybridization. |journal=Mamm. Genome |volume=7 |issue= 10 |pages= 791–2 |year= 1997 |pmid= 8854877 |doi=
*cite journal | author=Neerman-Arbez M, Antonarakis SE, Blouin JL, "et al." |title=The locus for combined factor V-factor VIII deficiency (F5F8D) maps to 18q21, between D18S849 and D18S1103. |journal=Am. J. Hum. Genet. |volume=61 |issue= 1 |pages= 143–50 |year= 1997 |pmid= 9245995 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Nichols WC, Seligsohn U, Zivelin A, "et al." |title=Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. |journal=Cell |volume=93 |issue= 1 |pages= 61–70 |year= 1998 |pmid= 9546392 |doi=
*cite journal | author=Nichols WC, Terry VH, Wheatley MA, "et al." |title=ERGIC-53 gene structure and mutation analysis in 19 combined factors V and VIII deficiency families. |journal=Blood |volume=93 |issue= 7 |pages= 2261–6 |year= 1999 |pmid= 10090935 |doi=
*cite journal | author=Saifuddin M, Hart ML, Gewurz H, "et al." |title=Interaction of mannose-binding lectin with primary isolates of human immunodeficiency virus type 1. |journal=J. Gen. Virol. |volume=81 |issue= Pt 4 |pages= 949–55 |year= 2000 |pmid= 10725420 |doi=
*cite journal | author=Harris RA, Yang A, Stein RC, "et al." |title=Cluster analysis of an extensive human breast cancer cell line protein expression map database. |journal=Proteomics |volume=2 |issue= 2 |pages= 212–23 |year= 2002 |pmid= 11840567 |doi=
*cite journal | author=Jüliger S, Kremsner PG, Alpers MP, "et al." |title=Restricted polymorphisms of the mannose-binding lectin gene in a population of Papua New Guinea. |journal=Mutat. Res. |volume=505 |issue= 1-2 |pages= 87–91 |year= 2002 |pmid= 12175909 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hart ML, Saifuddin M, Uemura K, "et al." |title=High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1. |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 17 |pages= 1311–7 |year= 2003 |pmid= 12487819 |doi= 10.1089/088922202320886352
*cite journal | author=Hart ML, Saifuddin M, Spear GT |title=Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin. |journal=J. Gen. Virol. |volume=84 |issue= Pt 2 |pages= 353–60 |year= 2003 |pmid= 12560567 |doi=
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=García-Laorden MI, Rúa-Figueroa I, Pérez-Aciego P, "et al." |title=Mannose binding lectin polymorphisms as a disease-modulating factor in women with systemic lupus erythematosus from Canary Islands, Spain. |journal=J. Rheumatol. |volume=30 |issue= 4 |pages= 740–6 |year= 2003 |pmid= 12672193 |doi=

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