Peroxiredoxin 2

Peroxiredoxin 2

Peroxiredoxin 2, also known as PRDX2, is a human gene.cite web | title = Entrez Gene: PRDX2 peroxiredoxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7001| accessdate = ]

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summary_text = This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.cite web | title = Entrez Gene: PRDX2 peroxiredoxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7001| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rasmussen HH, van Damme J, Puype M, "et al." |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960–9 |year= 1993 |pmid= 1286667 |doi=
*cite journal | author=Pahl P, Berger R, Hart I, "et al." |title=Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12. |journal=Genomics |volume=26 |issue= 3 |pages= 602–6 |year= 1995 |pmid= 7607688 |doi=
*cite journal | author=Shau H, Butterfield LH, Chiu R, Kim A |title=Cloning and sequence analysis of candidate human natural killer-enhancing factor genes. |journal=Immunogenetics |volume=40 |issue= 2 |pages= 129–34 |year= 1994 |pmid= 8026862 |doi=
*cite journal | author=Chae HZ, Robison K, Poole LB, "et al." |title=Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 15 |pages= 7017–21 |year= 1994 |pmid= 8041738 |doi=
*cite journal | author=Lim YS, Cha MK, Yun CH, "et al." |title=Purification and characterization of thiol-specific antioxidant protein from human red blood cell: a new type of antioxidant protein. |journal=Biochem. Biophys. Res. Commun. |volume=199 |issue= 1 |pages= 199–206 |year= 1994 |pmid= 8123012 |doi=
*cite journal | author=Lim YS, Cha MK, Kim HK, Kim IH |title=The thiol-specific antioxidant protein from human brain: gene cloning and analysis of conserved cysteine regions. |journal=Gene |volume=140 |issue= 2 |pages= 279–84 |year= 1994 |pmid= 8144038 |doi=
*cite journal | author=Golaz O, Hughes GJ, Frutiger S, "et al." |title=Plasma and red blood cell protein maps: update 1993. |journal=Electrophoresis |volume=14 |issue= 11 |pages= 1223–31 |year= 1994 |pmid= 8313871 |doi=
*cite journal | author=Cha MK, Kim IH |title=Glutathione-linked thiol peroxidase activity of human serum albumin: a possible antioxidant role of serum albumin in blood plasma. |journal=Biochem. Biophys. Res. Commun. |volume=222 |issue= 2 |pages= 619–25 |year= 1996 |pmid= 8670254 |doi= 10.1006/bbrc.1996.0793
*cite journal | author=Ji H, Reid GE, Moritz RL, "et al." |title=A two-dimensional gel database of human colon carcinoma proteins. |journal=Electrophoresis |volume=18 |issue= 3-4 |pages= 605–13 |year= 1997 |pmid= 9150948 |doi= 10.1002/elps.1150180344
*cite journal | author=Wang ZM, Liu C, Dziarski R |title=Chemokines are the main proinflammatory mediators in human monocytes activated by Staphylococcus aureus, peptidoglycan, and endotoxin. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20260–7 |year= 2000 |pmid= 10751418 |doi= 10.1074/jbc.M909168199
*cite journal | author=Cha MK, Yun CH, Kim IH |title=Interaction of human thiol-specific antioxidant protein 1 with erythrocyte plasma membrane. |journal=Biochemistry |volume=39 |issue= 23 |pages= 6944–50 |year= 2000 |pmid= 10841776 |doi=
*cite journal | author=Schröder E, Littlechild JA, Lebedev AA, "et al." |title=Crystal structure of decameric 2-Cys peroxiredoxin from human erythrocytes at 1.7 A resolution. |journal=Structure |volume=8 |issue= 6 |pages= 605–15 |year= 2000 |pmid= 10873855 |doi=
*cite journal | author=Harris JR, Schröder E, Isupov MN, "et al." |title=Comparison of the decameric structure of peroxiredoxin-II by transmission electron microscopy and X-ray crystallography. |journal=Biochim. Biophys. Acta |volume=1547 |issue= 2 |pages= 221–34 |year= 2001 |pmid= 11410278 |doi=
*cite journal | author=Noh DY, Ahn SJ, Lee RA, "et al." |title=Overexpression of peroxiredoxin in human breast cancer. |journal=Anticancer Res. |volume=21 |issue= 3B |pages= 2085–90 |year= 2001 |pmid= 11497302 |doi=
*cite journal | author=Kim SH, Fountoulakis M, Cairns N, Lubec G |title=Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 223–35 |year= 2002 |pmid= 11771746 |doi=
*cite journal | author=Rabilloud T, Heller M, Gasnier F, "et al." |title=Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19396–401 |year= 2002 |pmid= 11904290 |doi= 10.1074/jbc.M106585200
*cite journal | author=Anahory T, Dechaud H, Bennes R, "et al." |title=Identification of new proteins in follicular fluid of mature human follicles. |journal=Electrophoresis |volume=23 |issue= 7-8 |pages= 1197–202 |year= 2002 |pmid= 11981869 |doi= 10.1002/1522-2683(200204)23:7/8<1197::AID-ELPS1197>3.0.CO;2-2
*cite journal | author=Shen C, Nathan C |title=Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. |journal=Mol. Med. |volume=8 |issue= 2 |pages= 95–102 |year= 2002 |pmid= 12080185 |doi=
*cite journal | author=Geiben-Lynn R, Kursar M, Brown NV, "et al." |title=HIV-1 antiviral activity of recombinant natural killer cell enhancing factors, NKEF-A and NKEF-B, members of the peroxiredoxin family. |journal=J. Biol. Chem. |volume=278 |issue= 3 |pages= 1569–74 |year= 2003 |pmid= 12421812 |doi= 10.1074/jbc.M209964200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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