PRDX4

Peroxiredoxin 4, also known as PRDX4, is a human gene.cite web | title = Entrez Gene: PRDX4 peroxiredoxin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10549| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB.cite web | title = Entrez Gene: PRDX4 peroxiredoxin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10549| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jin DY, Chae HZ, Rhee SG, Jeang KT |title=Regulatory role for a novel human thioredoxin peroxidase in NF-kappaB activation. |journal=J. Biol. Chem. |volume=272 |issue= 49 |pages= 30952–61 |year= 1998 |pmid= 9388242 |doi=
*cite journal | author=Sasagawa I, Matsuki S, Suzuki Y, "et al." |title=Possible involvement of the membrane-bound form of peroxiredoxin 4 in acrosome formation during spermiogenesis of rats. |journal=Eur. J. Biochem. |volume=268 |issue= 10 |pages= 3053–61 |year= 2001 |pmid= 11358524 |doi=
*cite journal | author=Wagner E, Luche S, Penna L, "et al." |title=A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 777–85 |year= 2002 |pmid= 12059788 |doi= 10.1042/BJ20020525
*cite journal | author=Shen C, Nathan C |title=Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. |journal=Mol. Med. |volume=8 |issue= 2 |pages= 95–102 |year= 2002 |pmid= 12080185 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Leonard D, Ajuh P, Lamond AI, Legerski RJ |title=hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 4 |pages= 793–801 |year= 2003 |pmid= 12927788 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ahmed M, Forsberg J, Bergsten P |title=Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 3 |pages= 931–40 |year= 2005 |pmid= 15952740 |doi= 10.1021/pr050024a
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Guo D, Han J, Adam BL, "et al." |title=Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. |journal=Biochem. Biophys. Res. Commun. |volume=337 |issue= 4 |pages= 1308–18 |year= 2005 |pmid= 16236267 |doi= 10.1016/j.bbrc.2005.09.191
*cite journal | author=Giguère P, Turcotte ME, Hamelin E, "et al." |title=Peroxiredoxin-4 interacts with and regulates the thromboxane A(2) receptor. |journal=FEBS Lett. |volume=581 |issue= 20 |pages= 3863–8 |year= 2007 |pmid= 17644091 |doi= 10.1016/j.febslet.2007.07.011

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