- Trefoil factor 2
Trefoil factor 2 (spasmolytic protein 1), also known as TFF2, is a human
gene .cite web | title = Entrez Gene: TFF2 trefoil factor 2 (spasmolytic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7032| accessdate = ]Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved
disulfide s. They are stable secretoryprotein s expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of theepithelium . The encoded protein inhibitsgastric acid secretion. Thisgene and two other related trefoil family member genes are found in a cluster on chromosome 21.cite web | title = Entrez Gene: TFF2 trefoil factor 2 (spasmolytic protein 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7032| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892–906 |year= 1997 |pmid= 9272936 |doi=
*cite journal | author=Langer G, Jagla W, Behrens-Baumann W, "et al." |title=Ocular TFF-peptides: new mucus-associated secretory products of conjunctival goblet cells. |journal=Adv. Exp. Med. Biol. |volume=506 |issue= Pt A |pages= 313–6 |year= 2003 |pmid= 12613926 |doi=
*cite journal | author=Tomasetto C, Rockel N, Mattei MG, "et al." |title=The gene encoding the human spasmolytic protein (SML1/hSP) is in 21q 22.3, physically linked to the homologous breast cancer marker gene BCEI/pS2. |journal=Genomics |volume=13 |issue= 4 |pages= 1328–30 |year= 1992 |pmid= 1505966 |doi=
*cite journal | author=Tomasetto C, Rio MC, Gautier C, "et al." |title=hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. |journal=EMBO J. |volume=9 |issue= 2 |pages= 407–14 |year= 1990 |pmid= 2303034 |doi=
*cite journal | author=Bhogal N, Donnelly D, Findlay JB |title=The ligand binding site of the neurokinin 2 receptor. Site-directed mutagenesis and identification of neurokinin A binding residues in the human neurokinin 2 receptor. |journal=J. Biol. Chem. |volume=269 |issue= 44 |pages= 27269–74 |year= 1994 |pmid= 7961636 |doi=
*cite journal | author=Hanby AM, Poulsom R, Singh S, "et al." |title=Spasmolytic polypeptide is a major antral peptide: distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach. |journal=Gastroenterology |volume=105 |issue= 4 |pages= 1110–6 |year= 1993 |pmid= 8405856 |doi=
*cite journal | author=Itoh H, Tomita M, Uchino H, "et al." |title=cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis. |journal=Biochem. J. |volume=318 ( Pt 3) |issue= |pages= 939–44 |year= 1996 |pmid= 8836141 |doi=
*cite journal | author=Gött P, Beck S, Machado JC, "et al." |title=Human trefoil peptides: genomic structure in 21q22.3 and coordinated expression. |journal=Eur. J. Hum. Genet. |volume=4 |issue= 6 |pages= 308–15 |year= 1997 |pmid= 9043862 |doi=
*cite journal | author=May FE, Westley BR |title=Close physical linkage of the genes encoding the pNR-2/pS2 protein and human spasmolytic protein (hSP). |journal=Hum. Genet. |volume=99 |issue= 3 |pages= 303–7 |year= 1997 |pmid= 9050913 |doi=
*cite journal | author=Seib T, Blin N, Hilgert K, "et al." |title=The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. |journal=Genomics |volume=40 |issue= 1 |pages= 200–2 |year= 1997 |pmid= 9070946 |doi= 10.1006/geno.1996.4511
*cite journal | author=Kayademir T, Silva Edos S, Pusch C, "et al." |title=A novel 25 bp tandem repeat within the human trefoil peptide gene TFF2 in 21q22.3: polymorphism and mammalian evolution. |journal=Eur. J. Hum. Genet. |volume=6 |issue= 2 |pages= 121–8 |year= 1998 |pmid= 9781055 |doi= 10.1038/sj.ejhg.5200166
*cite journal | author=Brunelleschi S, Bordin G, Colangelo D, Viano I |title=Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis. |journal=Neuropeptides |volume=32 |issue= 3 |pages= 215–23 |year= 1999 |pmid= 10189055 |doi=
*cite journal | author=May FE, Semple JI, Newton JL, Westley BR |title=The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach. |journal=Gut |volume=46 |issue= 4 |pages= 454–9 |year= 2000 |pmid= 10716671 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Berry A, Scott HS, Kudoh J, "et al." |title=Refined localization of autosomal recessive nonsyndromic deafness DFNB10 locus using 34 novel microsatellite markers, genomic structure, and exclusion of six known genes in the region. |journal=Genomics |volume=68 |issue= 1 |pages= 22–9 |year= 2001 |pmid= 10950923 |doi= 10.1006/geno.2000.6253
*cite journal | author=Bulitta CJ, Fleming JV, Raychowdhury R, "et al." |title=Autoinduction of the trefoil factor 2 (TFF2) promoter requires an upstream cis-acting element. |journal=Biochem. Biophys. Res. Commun. |volume=293 |issue= 1 |pages= 366–74 |year= 2002 |pmid= 12054609 |doi= 10.1016/S0006-291X(02)00199-7
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Hu GY, Yu BP, Dong WG, "et al." |title=Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa. |journal=World J. Gastroenterol. |volume=9 |issue= 5 |pages= 910–4 |year= 2003 |pmid= 12717829 |doi=PBB_Controls
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