PRDX3

Peroxiredoxin 3, also known as PRDX3, is a human gene.cite web | title = Entrez Gene: PRDX3 peroxiredoxin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10935| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.cite web | title = Entrez Gene: PRDX3 peroxiredoxin 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10935| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, "et al." |title=Human liver protein
journal=Electrophoresis |volume=13 |issue= 12 |pages= 992–1001 |year= 1993 |pmid= 1286669 |doi=
*cite journal | author=Tsuji K, Copeland NG, Jenkins NA, Obinata M |title=Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli. |journal=Biochem. J. |volume=307 ( Pt 2) |issue= |pages= 377–81 |year= 1995 |pmid= 7733872 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Watabe S, Hiroi T, Yamamoto Y, "et al." |title=SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria. |journal=Eur. J. Biochem. |volume=249 |issue= 1 |pages= 52–60 |year= 1997 |pmid= 9363753 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Shih SF, Wu YH, Hung CH, "et al." |title=Abrin triggers cell death by inactivating a thiol-specific antioxidant protein. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21870–7 |year= 2001 |pmid= 11285261 |doi= 10.1074/jbc.M100571200
*cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, "et al." |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758–65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101
*cite journal | author=Kim SH, Fountoulakis M, Cairns N, Lubec G |title=Protein levels of human peroxiredoxin subtypes in brains of patients with Alzheimer's disease and Down syndrome. |journal=J. Neural Transm. Suppl. |volume= |issue= 61 |pages= 223–35 |year= 2002 |pmid= 11771746 |doi=
*cite journal | author=Rabilloud T, Heller M, Gasnier F, "et al." |title=Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19396–401 |year= 2002 |pmid= 11904290 |doi= 10.1074/jbc.M106585200
*cite journal | author=Wonsey DR, Zeller KI, Dang CV |title=The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 10 |pages= 6649–54 |year= 2002 |pmid= 12011429 |doi= 10.1073/pnas.102523299
*cite journal | author=Wagner E, Luche S, Penna L, "et al." |title=A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress. |journal=Biochem. J. |volume=366 |issue= Pt 3 |pages= 777–85 |year= 2002 |pmid= 12059788 |doi= 10.1042/BJ20020525
*cite journal | author=Shen C, Nathan C |title=Nonredundant antioxidant defense by multiple two-cysteine peroxiredoxins in human prostate cancer cells. |journal=Mol. Med. |volume=8 |issue= 2 |pages= 95–102 |year= 2002 |pmid= 12080185 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Masaki M, Ikeda A, Shiraki E, "et al." |title=Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. |journal=Eur. J. Biochem. |volume=270 |issue= 1 |pages= 76–83 |year= 2003 |pmid= 12492477 |doi=
*cite journal | author=Choi JH, Kim TN, Kim S, "et al." |title=Overexpression of mitochondrial thioredoxin reductase and peroxiredoxin III in hepatocellular carcinomas. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3331–5 |year= 2003 |pmid= 12530083 |doi=
*cite journal | author=Krapfenbauer K, Engidawork E, Cairns N, "et al." |title=Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders. |journal=Brain Res. |volume=967 |issue= 1-2 |pages= 152–60 |year= 2003 |pmid= 12650976 |doi=
*cite journal | author=Deloukas P, Earthrowl ME, Grafham DV, "et al." |title=The DNA sequence and comparative analysis of human chromosome 10. |journal=Nature |volume=429 |issue= 6990 |pages= 375–81 |year= 2004 |pmid= 15164054 |doi= 10.1038/nature02462
*cite journal | author=Chang TS, Cho CS, Park S, "et al." |title=Peroxiredoxin III, a mitochondrion-specific peroxidase, regulates apoptotic signaling by mitochondria. |journal=J. Biol. Chem. |volume=279 |issue= 40 |pages= 41975–84 |year= 2004 |pmid= 15280382 |doi= 10.1074/jbc.M407707200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liu L, Yang C, Yuan J, "et al." |title=RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains. |journal=Mol. Cells |volume=19 |issue= 1 |pages= 39–45 |year= 2005 |pmid= 15750338 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes