Tumor-associated calcium signal transducer 1

Tumor-associated calcium signal transducer 1

Tumor-associated calcium signal transducer 1, also known as TACSTD1, is a human gene.cite web | title = Entrez Gene: TACSTD1 tumor-associated calcium signal transducer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4072| accessdate = ] TACSTD1 has also been designated as CD326 (cluster of differentiation 326).

section_title =
summary_text = This 9-exon gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas.cite web | title = Entrez Gene: TACSTD1 tumor-associated calcium signal transducer 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4072| accessdate = ]


Further reading

citations =
*cite journal | author=Bergsagel PL, Victor-Kobrin C, Timblin CR, "et al." |title=A murine cDNA encodes a pan-epithelial glycoprotein that is also expressed on plasma cells. |journal=J. Immunol. |volume=148 |issue= 2 |pages= 590–6 |year= 1992 |pmid= 1729376 |doi=
*cite journal | author=Simon B, Podolsky DK, Moldenhauer G, "et al." |title=Epithelial glycoprotein is a member of a family of epithelial cell surface antigens homologous to nidogen, a matrix adhesion protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 7 |pages= 2755–9 |year= 1990 |pmid= 2108441 |doi=
*cite journal | author=Szala S, Froehlich M, Scollon M, "et al." |title=Molecular cloning of cDNA for the carcinoma-associated antigen GA733-2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 9 |pages= 3542–6 |year= 1990 |pmid= 2333300 |doi=
*cite journal | author=Strnad J, Hamilton AE, Beavers LS, "et al." |title=Molecular cloning and characterization of a human adenocarcinoma/epithelial cell surface antigen complementary DNA. |journal=Cancer Res. |volume=49 |issue= 2 |pages= 314–7 |year= 1989 |pmid= 2463074 |doi=
*cite journal | author=Perez MS, Walker LE |title=Isolation and characterization of a cDNA encoding the KS1/4 epithelial carcinoma marker. |journal=J. Immunol. |volume=142 |issue= 10 |pages= 3662–7 |year= 1989 |pmid= 2469722 |doi=
*cite journal | author=Linnenbach AJ, Wojcierowski J, Wu SA, "et al." |title=Sequence investigation of the major gastrointestinal tumor-associated antigen gene family, GA733. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 1 |pages= 27–31 |year= 1989 |pmid= 2911574 |doi=
*cite journal | author=Spurr NK, Durbin H, Sheer D, "et al." |title=Characterization and chromosomal assignment of a human cell surface antigen defined by the monoclonal antibody AUAI. |journal=Int. J. Cancer |volume=38 |issue= 5 |pages= 631–6 |year= 1986 |pmid= 3770992 |doi=
*cite journal | author=Björk P, Jönsson U, Svedberg H, "et al." |title=Isolation, partial characterization, and molecular cloning of a human colon adenocarcinoma cell-surface glycoprotein recognized by the C215 mouse monoclonal antibody. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24232–41 |year= 1993 |pmid= 7693697 |doi=
*cite journal | author=Linnenbach AJ, Seng BA, Wu S, "et al." |title=Retroposition in a family of carcinoma-associated antigen genes. |journal=Mol. Cell. Biol. |volume=13 |issue= 3 |pages= 1507–15 |year= 1993 |pmid= 8382772 |doi=
*cite journal | author=Zhong XY, Kaul S, Eichler A, Bastert G |title=Evaluating GA733-2 mRNA as a marker for the detection of micrometastatic breast cancer in peripheral blood and bone marrow. |journal=Arch. Gynecol. Obstet. |volume=263 |issue= 1-2 |pages= 2–6 |year= 2000 |pmid= 10728619 |doi=
*cite journal | author=Tomita Y, Arakawa F, Yamamoto T, "et al." |title=Molecular identification of a human carcinoma-associated glycoprotein antigen recognized by mouse monoclonal antibody FU-MK-1. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 2 |pages= 231–8 |year= 2000 |pmid= 10761711 |doi=
*cite journal | author=Trebak M, Begg GE, Chong JM, "et al." |title=Oligomeric state of the colon carcinoma-associated glycoprotein GA733-2 (Ep-CAM/EGP40) and its role in GA733-mediated homotypic cell-cell adhesion. |journal=J. Biol. Chem. |volume=276 |issue= 3 |pages= 2299–309 |year= 2001 |pmid= 11058587 |doi= 10.1074/jbc.M004770200
*cite journal | author=Chong JM, Speicher DW |title=Determination of disulfide bond assignments and N-glycosylation sites of the human gastrointestinal carcinoma antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM). |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5804–13 |year= 2001 |pmid= 11080501 |doi= 10.1074/jbc.M008839200
*cite journal | author=Calabrese G, Crescenzi C, Morizio E, "et al." |title=Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=92 |issue= 1-2 |pages= 164–5 |year= 2001 |pmid= 11306819 |doi=
*cite journal | author=Meyaard L, van der Vuurst de Vries AR, de Ruiter T, "et al." |title=The epithelial cellular adhesion molecule (Ep-CAM) is a ligand for the leukocyte-associated immunoglobulin-like receptor (LAIR). |journal=J. Exp. Med. |volume=194 |issue= 1 |pages= 107–12 |year= 2001 |pmid= 11435477 |doi=
*cite journal | author=Lammers R, Giesert C, Grünebach F, "et al." |title=Monoclonal antibody 9C4 recognizes epithelial cellular adhesion molecule, a cell surface antigen expressed in early steps of erythropoiesis. |journal=Exp. Hematol. |volume=30 |issue= 6 |pages= 537–45 |year= 2002 |pmid= 12063020 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Spizzo G, Gastl G, Wolf D, "et al." |title=Correlation of COX-2 and Ep-CAM overexpression in human invasive breast cancer and its impact on survival. |journal=Br. J. Cancer |volume=88 |issue= 4 |pages= 574–8 |year= 2003 |pmid= 12592372 |doi= 10.1038/sj.bjc.6600741
*cite journal | author=Nasr AF, Nutini M, Palombo B, "et al." |title=Mutations of TP53 induce loss of DNA methylation and amplification of the TROP1 gene. |journal=Oncogene |volume=22 |issue= 11 |pages= 1668–77 |year= 2003 |pmid= 12642870 |doi= 10.1038/sj.onc.1206248
*cite journal | author=Gires O, Eskofier S, Lang S, "et al." |title=Cloning and characterisation of a 1.1 kb fragment of the carcinoma-associated epithelial cell adhesion molecule promoter. |journal=Anticancer Res. |volume=23 |issue= 4 |pages= 3255–61 |year= 2003 |pmid= 12926061 |doi=

External links


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