Peptidase inhibitor 3

Peptidase inhibitor 3

Peptidase inhibitor 3, skin-derived (SKALP), also known as PI3, is a human gene.cite web | title = Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)| url =| accessdate = ]

section_title =
summary_text = This gene encodes an elastase-specific inhibitor, which contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster.cite web | title = Entrez Gene: PI3 peptidase inhibitor 3, skin-derived (SKALP)| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Sallenave JM |title=The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease. |journal=Respir. Res. |volume=1 |issue= 2 |pages= 87–92 |year= 2003 |pmid= 11667971 |doi=
*cite journal | author=Saheki T, Ito F, Hagiwara H, "et al." |title=Primary structure of the human elafin precursor preproelafin deduced from the nucleotide sequence of its gene and the presence of unique repetitive sequences in the prosegment. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 1 |pages= 240–5 |year= 1992 |pmid= 1339270 |doi=
*cite journal | author=Sallenave JM, Marsden MD, Ryle AP |title=Isolation of elafin and elastase-specific inhibitor (ESI) from bronchial secretions. Evidence of sequence homology and immunological cross-reactivity. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 1 |pages= 27–33 |year= 1992 |pmid= 1536690 |doi=
*cite journal | author=Chang A, Schalkwijk J, Happle R, van de Kerkhof PC |title=Elastase-inhibiting activity in scaling skin disorders. |journal=Acta Derm. Venereol. |volume=70 |issue= 2 |pages= 147–51 |year= 1990 |pmid= 1969201 |doi=
*cite journal | author=Schalkwijk J, de Roo C, de Jongh GJ |title=Skin-derived antileukoproteinase (SKALP), an elastase inhibitor from human keratinocytes. Purification and biochemical properties. |journal=Biochim. Biophys. Acta |volume=1096 |issue= 2 |pages= 148–54 |year= 1991 |pmid= 2001428 |doi=
*cite journal | author=Sallenave JM, Ryle AP |title=Purification and characterization of elastase-specific inhibitor. Sequence homology with mucus proteinase inhibitor. |journal=Biol. Chem. Hoppe-Seyler |volume=372 |issue= 1 |pages= 13–21 |year= 1991 |pmid= 2039600 |doi=
*cite journal | author=Wiedow O, Schröder JM, Gregory H, "et al." |title=Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence. |journal=J. Biol. Chem. |volume=265 |issue= 25 |pages= 14791–5 |year= 1990 |pmid= 2394696 |doi=
*cite journal | author=Molhuizen HO, Alkemade HA, Zeeuwen PL, "et al." |title=SKALP/elafin: an elastase inhibitor from cultured human keratinocytes. Purification, cDNA sequence, and evidence for transglutaminase cross-linking. |journal=J. Biol. Chem. |volume=268 |issue= 16 |pages= 12028–32 |year= 1993 |pmid= 7685029 |doi=
*cite journal | author=Zhang M, Zou Z, Maass N, Sager R |title=Differential expression of elafin in human normal mammary epithelial cells and carcinomas is regulated at the transcriptional level. |journal=Cancer Res. |volume=55 |issue= 12 |pages= 2537–41 |year= 1995 |pmid= 7780965 |doi=
*cite journal | author=Molhuizen HO, Zeeuwen PL, Olde Weghuis D, "et al." |title=Assignment of the human gene encoding the epidermal serine proteinase inhibitor SKALP (PI3) to chromosome region 20q12-->q13. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 2 |pages= 129–31 |year= 1994 |pmid= 8287685 |doi=
*cite journal | author=Sallenave JM, Silva A |title=Characterization and gene sequence of the precursor of elafin, an elastase-specific inhibitor in bronchial secretions. |journal=Am. J. Respir. Cell Mol. Biol. |volume=8 |issue= 4 |pages= 439–45 |year= 1993 |pmid= 8476637 |doi=
*cite journal | author=Tsunemi M, Matsuura Y, Sakakibara S, Katsube Y |title=Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution. |journal=Biochemistry |volume=35 |issue= 36 |pages= 11570–6 |year= 1996 |pmid= 8794736 |doi= 10.1021/bi960900l
*cite journal | author=Pfundt R, van Ruissen F, van Vlijmen-Willems IM, "et al." |title=Constitutive and inducible expression of SKALP/elafin provides anti-elastase defense in human epithelia. |journal=J. Clin. Invest. |volume=98 |issue= 6 |pages= 1389–99 |year= 1996 |pmid= 8823304 |doi=
*cite journal | author=Steinert PM, Marekov LN |title=Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope. |journal=J. Biol. Chem. |volume=272 |issue= 3 |pages= 2021–30 |year= 1997 |pmid= 8999895 |doi=
*cite journal | author=Francart C, Dauchez M, Alix AJ, Lippens G |title=Solution structure of R-elafin, a specific inhibitor of elastase. |journal=J. Mol. Biol. |volume=268 |issue= 3 |pages= 666–77 |year= 1997 |pmid= 9171290 |doi= 10.1006/jmbi.1997.0983
*cite journal | author=Kuijpers AL, Pfundt R, Zeeuwen PL, "et al." |title=SKALP/elafin gene polymorphisms are not associated with pustular forms of psoriasis. |journal=Clin. Genet. |volume=54 |issue= 1 |pages= 96–101 |year= 1998 |pmid= 9727750 |doi=
*cite journal | author=Mihaila A, Tremblay GM |title=Human alveolar macrophages express elafin and secretory leukocyte protease inhibitor. |journal=Z. Naturforsch., C, J. Biosci. |volume=56 |issue= 3-4 |pages= 291–7 |year= 2001 |pmid= 11371023 |doi=
*cite journal | author=Simpson AJ, Wallace WA, Marsden ME, "et al." |title=Adenoviral augmentation of elafin protects the lung against acute injury mediated by activated neutrophils and bacterial infection. |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1778–86 |year= 2001 |pmid= 11466403 |doi=
*cite journal | author=Sumi Y, Inoue N, Azumi H, "et al." |title=Expression of tissue transglutaminase and elafin in human coronary artery: implication for plaque instability. |journal=Atherosclerosis |volume=160 |issue= 1 |pages= 31–9 |year= 2002 |pmid= 11755920 |doi=

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