ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2, also known as ABCC2, is a human gene.cite web | title = Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1244| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily, which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.cite web | title = Entrez Gene: ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1244| accessdate = ]

ee also

* ATP-binding cassette transporter

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keppler D, König J |title=Hepatic secretion of conjugated drugs and endogenous substances. |journal=Semin. Liver Dis. |volume=20 |issue= 3 |pages= 265–72 |year= 2001 |pmid= 11076395 |doi=
*cite journal | author=Gerk PM, Vore M |title=Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. |journal=J. Pharmacol. Exp. Ther. |volume=302 |issue= 2 |pages= 407–15 |year= 2002 |pmid= 12130697 |doi= 10.1124/jpet.102.035014
*cite journal | author=Mayer R, Kartenbeck J, Büchler M, "et al." |title=Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes. |journal=J. Cell Biol. |volume=131 |issue= 1 |pages= 137–50 |year= 1995 |pmid= 7559771 |doi=
*cite journal | author=Büchler M, König J, Brom M, "et al." |title=cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15091–8 |year= 1996 |pmid= 8662992 |doi=
*cite journal | author=Taniguchi K, Wada M, Kohno K, "et al." |title=A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. |journal=Cancer Res. |volume=56 |issue= 18 |pages= 4124–9 |year= 1996 |pmid= 8797578 |doi=
*cite journal | author=Paulusma CC, Kool M, Bosma PJ, "et al." |title=A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. |journal=Hepatology |volume=25 |issue= 6 |pages= 1539–42 |year= 1997 |pmid= 9185779 |doi= 10.1002/hep.510250635
*cite journal | author=van Kuijck MA, Kool M, Merkx GF, "et al." |title=Assignment of the canalicular multispecific organic anion transporter gene (CMOAT) to human chromosome 10q24 and mouse chromosome 19D2 by fluorescent in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 285–7 |year= 1997 |pmid= 9284939 |doi=
*cite journal | author=Wada M, Toh S, Taniguchi K, "et al." |title=Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome. |journal=Hum. Mol. Genet. |volume=7 |issue= 2 |pages= 203–7 |year= 1998 |pmid= 9425227 |doi=
*cite journal | author=Evers R, Kool M, van Deemter L, "et al." |title=Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. |journal=J. Clin. Invest. |volume=101 |issue= 7 |pages= 1310–9 |year= 1998 |pmid= 9525973 |doi=
*cite journal | author=Kajihara S, Hisatomi A, Mizuta T, "et al." |title=A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome. |journal=Biochem. Biophys. Res. Commun. |volume=253 |issue= 2 |pages= 454–7 |year= 1999 |pmid= 9878557 |doi= 10.1006/bbrc.1998.9780
*cite journal | author=Toh S, Wada M, Uchiumi T, "et al." |title=Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome. |journal=Am. J. Hum. Genet. |volume=64 |issue= 3 |pages= 739–46 |year= 1999 |pmid= 10053008 |doi=
*cite journal | author=Schaub TP, Kartenbeck J, König J, "et al." |title=Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma. |journal=J. Am. Soc. Nephrol. |volume=10 |issue= 6 |pages= 1159–69 |year= 1999 |pmid= 10361853 |doi=
*cite journal | author=Tsujii H, König J, Rost D, "et al." |title=Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome. |journal=Gastroenterology |volume=117 |issue= 3 |pages= 653–60 |year= 1999 |pmid= 10464142 |doi=
*cite journal | author=Kocher O, Comella N, Gilchrist A, "et al." |title=PDZK1, a novel PDZ domain-containing protein up-regulated in carcinomas and mapped to chromosome 1q21, interacts with cMOAT (MRP2), the multidrug resistance-associated protein. |journal=Lab. Invest. |volume=79 |issue= 9 |pages= 1161–70 |year= 1999 |pmid= 10496535 |doi=
*cite journal | author=Tanaka T, Uchiumi T, Hinoshita E, "et al." |title=The human multidrug resistance protein 2 gene: functional characterization of the 5'-flanking region and expression in hepatic cells. |journal=Hepatology |volume=30 |issue= 6 |pages= 1507–12 |year= 1999 |pmid= 10573531 |doi= 10.1002/hep.510300617
*cite journal | author=St-Pierre MV, Serrano MA, Macias RI, "et al." |title=Expression of members of the multidrug resistance protein family in human term placenta. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=279 |issue= 4 |pages= R1495–503 |year= 2000 |pmid= 11004020 |doi=
*cite journal | author=Keitel V, Kartenbeck J, Nies AT, "et al." |title=Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome. |journal=Hepatology |volume=32 |issue= 6 |pages= 1317–28 |year= 2001 |pmid= 11093739 |doi= 10.1053/jhep.2000.19791
*cite journal | author=Ito S, Ieiri I, Tanabe M, "et al." |title=Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects. |journal=Pharmacogenetics |volume=11 |issue= 2 |pages= 175–84 |year= 2001 |pmid= 11266082 |doi=
*cite journal | author=Mor-Cohen R, Zivelin A, Rosenberg N, "et al." |title=Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 36923–30 |year= 2001 |pmid= 11477083 |doi= 10.1074/jbc.M105047200

External links

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