MRNA guanylyltransferase

In enzymology, a mRNA guanylyltransferase (EC number|2.7.7.50) is an enzyme that catalyzes the chemical reaction

:GTP + (5')ppPur-mRNA $ightleftharpoons$ diphosphate + G(5')pppPur-mRNA

Thus, the two substrates of this enzyme are GTP and (5')ppPur-mRNA, whereas its two products are diphosphate and G(5')pppPur-mRNA.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GTP:mRNA guanylyltransferase. Other names in common use include mRNA capping enzyme, messenger RNA guanylyltransferase, and Protein 2.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1CKM, PDB link|1CKN, PDB link|1CKO, PDB link|1P16, and PDB link|2C46.

References

*
*
*
*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|56941-23-2."

Gene Ontology (GO) codes