Diphosphoinositol-pentakisphosphate kinase

Diphosphoinositol-pentakisphosphate kinase
Identifiers
EC number	2.7.4.24
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles

In enzymology, a diphosphoinositol-pentakisphosphate kinase (EC 2.7.4.24) is an enzyme that catalyzes the chemical reaction

ATP + 1D-myo-inositol 5-diphosphate pentakisphosphate $\rightleftharpoons$ ADP + 1D-myo-inositol bisdiphosphate tetrakisphosphate (isomeric configuration unknown)

Thus, the two substrates of this enzyme are ATP and 1D-myo-inositol 5-diphosphate pentakisphosphate, whereas its 3 products are ADP, 1D-myo-inositol bisdiphosphate tetrakisphosphate and (isomeric configuration unknown).

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. The systematic name of this enzyme class is ATP:1D-myo-inositol-5-diphosphate-pentakisphosphate phosphotransferase. Other names in common use include PP-IP5 kinase, diphosphoinositol pentakisphosphate kinase, and ATP:5-diphospho-1D-myo-inositol-pentakisphosphate phosphotransferase.

References

• Shears SB, Ali N, Craxton A, Bembenek ME (1995). "Synthesis and metabolism of bis-diphosphoinositol tetrakisphosphate in vitro and in vivo". J. Biol. Chem. 270 (18): 10489–97. doi:10.1074/jbc.270.18.10489. PMID 7737983. 
• Brocker M, Shears SB, Mayr GW (Pt 2). "Biological variability in the structures of diphosphoinositol polyphosphates in Dictyostelium discoideum and mammalian cells". Biochem. J. 327: 553–60. PMC 1218829. PMID 9359429. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1218829. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.7.4 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем сделать НИР Hallucinating (album) Sam Llanas Look at other dictionaries: List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia IHPK2 — Inositol hexaphosphate kinase 2, also known as IHPK2, is a human gene.cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51447| accessdate …   Wikipedia IHPK1 — Inositol hexaphosphate kinase 1, also known as IHPK1, is a human gene.cite web | title = Entrez Gene: IHPK1 inositol hexaphosphate kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9807| accessdate …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”