IHPK2

Inositol hexaphosphate kinase 2, also known as IHPK2, is a human gene.cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51447| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: IHPK2 inositol hexaphosphate kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51447| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=White KE, Econs MJ |title=Localization of PiUS, a stimulator of cellular phosphate uptake to human chromosome 3p21.3. |journal=Somat. Cell Mol. Genet. |volume=24 |issue= 1 |pages= 71–4 |year= 1998 |pmid= 9776982 |doi=
*cite journal | author=Saiardi A, Erdjument-Bromage H, Snowman AM, "et al." |title=Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. |journal=Curr. Biol. |volume=9 |issue= 22 |pages= 1323–6 |year= 2000 |pmid= 10574768 |doi=
*cite journal | author=Saiardi A, Caffrey JJ, Snyder SH, Shears SB |title=The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. |journal=J. Biol. Chem. |volume=275 |issue= 32 |pages= 24686–92 |year= 2000 |pmid= 10827188 |doi= 10.1074/jbc.M002750200
*cite journal | author=Morrison BH, Bauer JA, Kalvakolanu DV, Lindner DJ |title=Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24965–70 |year= 2001 |pmid= 11337497 |doi= 10.1074/jbc.M101161200
*cite journal | author=Saiardi A, Nagata E, Luo HR, "et al." |title=Identification and characterization of a novel inositol hexakisphosphate kinase. |journal=J. Biol. Chem. |volume=276 |issue= 42 |pages= 39179–85 |year= 2001 |pmid= 11502751 |doi= 10.1074/jbc.M106842200
*cite journal | author=Morrison BH, Bauer JA, Hu J, "et al." |title=Inositol hexakisphosphate kinase 2 sensitizes ovarian carcinoma cells to multiple cancer therapeutics. |journal=Oncogene |volume=21 |issue= 12 |pages= 1882–9 |year= 2002 |pmid= 11896621 |doi= 10.1038/sj.onc.1205265
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Nagata E, Luo HR, Saiardi A, "et al." |title=Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. |journal=J. Biol. Chem. |volume=280 |issue= 2 |pages= 1634–40 |year= 2005 |pmid= 15533939 |doi= 10.1074/jbc.M409416200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Morrison BH, Bauer JA, Lupica JA, "et al." |title=Effect of inositol hexakisphosphate kinase 2 on transforming growth factor beta-activated kinase 1 and NF-kappaB activation. |journal=J. Biol. Chem. |volume=282 |issue= 21 |pages= 15349–56 |year= 2007 |pmid= 17379600 |doi= 10.1074/jbc.M700156200

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