Thymidine phosphorylase

In enzymology, a thymidine phosphorylase (EC number|2.4.2.4) is an enzyme that catalyzes the chemical reaction

:thymidine + phosphate $ightleftharpoons$ thymine + 2-deoxy-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are thymidine and phosphate, whereas its two products are thymine and 2-deoxy-alpha-D-ribose 1-phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is thymidine:phosphate deoxy-alpha-D-ribosyltransferase. Other names in common use include pyrimidine phosphorylase, thymidine-orthophosphate deoxyribosyltransferase, animal growth regulators, blood platelet-derived endothelial cell, growth factors, blood platelet-derived endothelial cell growth factor, deoxythymidine phosphorylase, gliostatins, pyrimidine deoxynucleoside phosphorylase, and thymidine:phosphate deoxy-D-ribosyltransferase. This enzyme participates in 3 metabolic pathways: purine metabolism, pyrimidine metabolism, and bladder cancer.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AZY, PDB link|1OTP, PDB link|1TPT, PDB link|1UOU, PDB link|2J0F, and PDB link|2TPT.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9030-23-3."

Gene Ontology (GO) codes