ECGF1

Endothelial cell growth factor 1 (platelet-derived), also known as ECGF1, is a human gene.

PBB_Summary
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summary_text = Platelet-derived endothelial cell growth factor (ECGF1) is an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. Because it limits glial cell proliferation, ECGF1 is also known as thymidine phosphorylase and as gliostatin. The ECGF1 gene contains 10 exons spanning more than 4.3 kb. Thymidine phosphorylase activity of ECGF1 in leukocytes from mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) patients was less than 5 percent of controls, indicating that loss-of-function mutations in thymidine phosphorylase cause MNGIE. [cite web | title = Entrez Gene: ECGF1 endothelial cell growth factor 1 (platelet-derived)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1890| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yang Q, Yoshimura G, Mori I, "et al." |title=Thymidine phosphorylase and breast carcinoma. |journal=Anticancer Res. |volume=22 |issue= 4 |pages= 2355–60 |year= 2002 |pmid= 12174926 |doi=
*cite journal | author=Asai K, Nakanishi K, Isobe I, "et al." |title=Neurotrophic action of gliostatin on cortical neurons. Identity of gliostatin and platelet-derived endothelial cell growth factor. |journal=J. Biol. Chem. |volume=267 |issue= 28 |pages= 20311–6 |year= 1992 |pmid= 1400349 |doi=
*cite journal | author=Furukawa T, Yoshimura A, Sumizawa T, "et al." |title=Angiogenic factor. |journal=Nature |volume=356 |issue= 6371 |pages= 668 |year= 1992 |pmid= 1570012 |doi= 10.1038/356668a0
*cite journal | author=Usuki K, Saras J, Waltenberger J, "et al." |title=Platelet-derived endothelial cell growth factor has thymidine phosphorylase activity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 3 |pages= 1311–6 |year= 1992 |pmid= 1590793 |doi=
*cite journal | author=Stenman G, Sahlin P, Dumanski JP, "et al." |title=Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13. |journal=Cytogenet. Cell Genet. |volume=59 |issue= 1 |pages= 22–3 |year= 1992 |pmid= 1733667 |doi=
*cite journal | author=Hagiwara K, Stenman G, Honda H, "et al." |title=Organization and chromosomal localization of the human platelet-derived endothelial cell growth factor gene. |journal=Mol. Cell. Biol. |volume=11 |issue= 4 |pages= 2125–32 |year= 1991 |pmid= 2005900 |doi=
*cite journal | author=Ishikawa F, Miyazono K, Hellman U, "et al." |title=Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. |journal=Nature |volume=338 |issue= 6216 |pages= 557–62 |year= 1989 |pmid= 2467210 |doi= 10.1038/338557a0
*cite journal | author=Bardosi A, Creutzfeldt W, DiMauro S, "et al." |title=Myo-, neuro-, gastrointestinal encephalopathy (MNGIE syndrome) due to partial deficiency of cytochrome-c-oxidase. A new mitochondrial multisystem disorder. |journal=Acta Neuropathol. |volume=74 |issue= 3 |pages= 248–58 |year= 1987 |pmid= 2823522 |doi=
*cite journal | author=Miyazono K, Okabe T, Urabe A, "et al." |title=Purification and properties of an endothelial cell growth factor from human platelets. |journal=J. Biol. Chem. |volume=262 |issue= 9 |pages= 4098–103 |year= 1987 |pmid= 3549724 |doi=
*cite journal | author=Usuki K, Gonez LJ, Wernstedt C, "et al." |title=Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/thymidine phosphorylase in A431 cells. |journal=Biochim. Biophys. Acta |volume=1222 |issue= 3 |pages= 411–4 |year= 1994 |pmid= 8038210 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hirano M, Silvestri G, Blake DM, "et al." |title=Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): clinical, biochemical, and genetic features of an autosomal recessive mitochondrial disorder. |journal=Neurology |volume=44 |issue= 4 |pages= 721–7 |year= 1994 |pmid= 8164833 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Stevenson DP, Milligan SR, Collins WP |title=Effects of platelet-derived endothelial cell growth factor/thymidine phosphorylase, substrate, and products in a three-dimensional model of angiogenesis. |journal=Am. J. Pathol. |volume=152 |issue= 6 |pages= 1641–6 |year= 1998 |pmid= 9626068 |doi=
*cite journal | author=Nishino I, Spinazzola A, Hirano M |title=Thymidine phosphorylase gene mutations in MNGIE, a human mitochondrial disorder. |journal=Science |volume=283 |issue= 5402 |pages= 689–92 |year= 1999 |pmid= 9924029 |doi=
*cite journal | author=Asgari MM, Haggerty JG, McNiff JM, "et al." |title=Expression and localization of thymidine phosphorylase/platelet-derived endothelial cell growth factor in skin and cutaneous tumors. |journal=J. Cutan. Pathol. |volume=26 |issue= 6 |pages= 287–94 |year= 1999 |pmid= 10472757 |doi=
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Sivridis E, Giatromanolaki A, Koukourakis MI, "et al." |title=Thymidine phosphorylase expression in normal and hyperplastic endometrium. |journal=J. Clin. Pathol. |volume=53 |issue= 9 |pages= 704–8 |year= 2000 |pmid= 11041061 |doi=
*cite journal | author=Komatsu T, Yamazaki H, Shimada N, "et al." |title=Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver. |journal=Clin. Cancer Res. |volume=7 |issue= 3 |pages= 675–81 |year= 2001 |pmid= 11297264 |doi=
*cite journal | author=Kojima H, Shijubo N, Abe S |title=Thymidine phosphorylase and vascular endothelial growth factor in patients with Stage I lung adenocarcinoma. |journal=Cancer |volume=94 |issue= 4 |pages= 1083–93 |year= 2002 |pmid= 11920479 |doi=

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