NAD+-diphthamide ADP-ribosyltransferase

In enzymology, a NAD+-diphthamide ADP-ribosyltransferase (EC number|2.4.2.36) is an enzyme that catalyzes the chemical reaction

:NAD⁺ + peptide diphthamide $ightleftharpoons$ nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide

Thus, the two substrates of this enzyme are NAD⁺ and peptide diphthamide, whereas its two products are nicotinamide and peptide N-(ADP-D-ribosyl)diphthamide.

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is NAD+:peptide-diphthamide N-(ADP-D-ribosyl)transferase. Other names in common use include ADP-ribosyltransferase, mono(ADPribosyl)transferase, and NAD-diphthamide ADP-ribosyltransferase.

tructural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1S5B, PDB link|1S5C, PDB link|1S5D, PDB link|1S5E, PDB link|1S5F, PDB link|1SGK, PDB link|1TOX, PDB link|1XDT, PDB link|1XK9, PDB link|1ZM3, PDB link|1ZM4, PDB link|1ZM9, PDB link|2A5D, PDB link|2A5F, and PDB link|2A5G.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|52933-21-8."

Gene Ontology (GO) codes