NAD(P)+-protein-arginine ADP-ribosyltransferase

In enzymology, a NAD(P)+-protein-arginine ADP-ribosyltransferase (EC number|2.4.2.31) is an enzyme that catalyzes the chemical reaction using nicotinamide adenine dinucleotide

:NAD⁺ + protein L-arginine $ightleftharpoons$ nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine NADP⁺ + protein L-arginine $ightleftharpoons$ nicotinamide + Nomega- [(2'-phospho-ADP)-D-ribosyl] -protein-L-arginine

as well as the corresponding reaction using nicotinamide adenine dinucleotide phosphate

:NADP⁺ + protein L-arginine $ightleftharpoons$ nicotinamide + Nomega-(ADP-D-ribosyl)-protein-L-arginine NADP⁺ + protein L-arginine $ightleftharpoons$ nicotinamide + Nomega- [(2'-phospho-ADP)-D-ribosyl] -protein-L-arginine

Thus, the two substrates of this enzyme are NAD⁺ (or NADP⁺) and protein L-arginine, whereas its two products are nicotinamide and Nomega-(ADP-D-ribosyl)-protein-L-arginine (or Nomega- [(2'-phospho-ADP)-D-ribosyl] -protein-L-arginine, respectively).

This enzyme belongs to the family of glycosyltransferases, specifically the pentosyltransferases. The systematic name of this enzyme class is NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase. Other names in common use include ADP-ribosyltransferase, mono(ADP-ribosyl)transferase, NAD+:L-arginine ADP-D-ribosyltransferase, NAD(P)+-arginine ADP-ribosyltransferase, NAD(P)+-arginine ADP-ribosyltransferase, and NAD(P)+:L-arginine ADP-D-ribosyltransferase.

tructural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GXY, PDB link|1GXZ, PDB link|1GY0, PDB link|1OG1, PDB link|1OG3, and PDB link|1OG4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|81457-93-4."

Gene Ontology (GO) codes