Kynurenine-oxoglutarate transaminase
- Kynurenine-oxoglutarate transaminase
In enzymology, a kynurenine-oxoglutarate transaminase (EC number|2.6.1.7) is an enzyme that catalyzes the chemical reaction
:L-kynurenine + 2-oxoglutarate 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate
Thus, the two substrates of this enzyme are L-kynurenine and 2-oxoglutarate, whereas its two products are 4-(2-aminophenyl)-2,4-dioxobutanoate and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is L-kynurenine:2-oxoglutarate aminotransferase. Other names in common use include kynurenine transaminase (cyclizing), kynurenine 2-oxoglutarate transaminase, kynurenine aminotransferase, and L-kynurenine aminotransferase. This enzyme participates in tryptophan metabolism. It employs one cofactor, pyridoxal phosphate.
tructural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1X0M, PDB link|1YIY, 1W7L, and PDB link|1YIZ.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9030-38-0."
Gene Ontology (GO) codes
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Look at other dictionaries:
Kynurenine — Chembox new ImageFile=Kynurenine.svg ImageSize= IUPACName=2 amino 4 (2 aminophenyl) 4 oxo butanoic acid OtherNames= Section1= Chembox Identifiers CASNo=343 65 7 PubChem=846 SMILES=C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N MeSHName=Kynurenine Section2=… … Wikipedia
Kynurénine — Énantiomère R (D) de la kynurénine (à gauche) et S kynurénine (L) (à droite) Général … Wikipédia en Français
Kynurenine — Général Nom IUPAC 2 amino 4 (2 aminophenyl) 4 oxo butanoic acid … Wikipédia en Français
List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… … Wikipedia
Kynurenic acid — Chembox new Name = Kynurenic acid ImageFile = KynurenicAcid.png ImageName = Chemical structure of kynurenic acid IUPACName = 4 oxo 1H quinoline 2 carboxylic acid OtherNames = Kinurenic acid, kynuronic acid, quinurenic acid, transtorine Section1 … Wikipedia
343-65-7 — Kynurenine Kynurenine Général Nom IUPAC 2 amino 4 (2 aminophenyl) 4 oxo butanoic acid … Wikipédia en Français
C10H12N2O3 — Kynurenine Kynurenine Général Nom IUPAC 2 amino 4 (2 aminophenyl) 4 oxo butanoic acid … Wikipédia en Français