Protein geranylgeranyltransferase type I

In enzymology, a protein geranylgeranyltransferase type I (EC number|2.5.1.59) is an enzyme that catalyzes the chemical reaction

:geranylgeranyl diphosphate + protein-cysteine $ightleftharpoons$ S-geranylgeranyl-protein + diphosphate

Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and protein-cysteine, whereas its two products are S-geranylgeranyl-protein and diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl-diphosphate:protein-cysteine geranyltransferase. Other names in common use include GGTase-I, and GGTaseI.

tructural studies

As of late 2007, 17 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1S63, PDB link|1S64, PDB link|1SA4, PDB link|1SA5, PDB link|1TNB, PDB link|1TNO, PDB link|1TNU, PDB link|1TNY, PDB link|1TNZ, PDB link|1X81, PDB link|2BED, PDB link|2F0Y, PDB link|2H6F, PDB link|2H6G, PDB link|2H6H, PDB link|2H6I, and PDB link|2IEJ.

References

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* Sinnott, M. (Ed.), Comprehensive Biological Catalysis. A Mechanistic Reference, vol. 1, Academic Press, San Diego, CA, 1998, p. 31-118.

External links

Gene Ontology (GO) codes