Rab geranylgeranyltransferase
- Rab geranylgeranyltransferase
protein
Name=Rab geranylgeranyltransferase, alpha subunit
caption=
width=
HGNCid=9795
Symbol=RABGGTA
AltSymbols=
EntrezGene=5875
OMIM=601905
RefSeq=NM_004581
UniProt=Q92696
PDB=
ECnumber=
Chromosome=14
Arm=q
Band=11.2
LocusSupplementaryData=protein
Name=Rab geranylgeranyltransferase, beta subunit
caption=
width=
HGNCid=9796
Symbol=RABGGTB
AltSymbols=
EntrezGene=5876
OMIM=179080
RefSeq=NM_004582
UniProt=P53611
PDB=
ECnumber=
Chromosome=1
Arm=p
Band=31
LocusSupplementaryData=
Rab geranylgeranyltransferase, or Geranylgeranyltransferase II is one of the three prenyltransferases. It transfers (usually) two geranylgeranyl groups to the cystein(s) at the C-terminus of Rab proteins.
The C-terminus of Rab proteins varies in length and sequence and is referred to as hypervariable. Thus Rab proteins do not have a consensus sequence, such as the CAAX box, which the Rab geranylgeranyltransferase can recognise. Instead Rab proteins are bound by the Rab escort protein (REP) over a more conserved region of the Rab protein and then presented to the Rab geranylgeranyltransferase.
Once Rab proteins are prenylated the lipid anchor(s) ensure that Rabs are no longer soluble. REP therefore plays an important role in binding and solubilising the geranylgeranyl groups and delivers the Rab protein to the relevant cell membrane.
ee also
* Prenylation
* Farnesyltransferase
* Geranylgeranyltransferase type 1 - also referred to as Geranylgeranyltranferase 1 or just Geranylgeranyltranferase
External links
*
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2010.
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