- Chrysanthemyl diphosphate synthase
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Chrysanthemyl diphosphate synthase Identifiers EC number 2.5.1.67 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Search PMC articles PubMed articles In enzymology, a chrysanthemyl diphosphate synthase (EC 2.5.1.67) is an enzyme involved in the biosynthesis of terpenoids. This enzyme is also known as CPPase. It catalyzes the chemical reaction shown below (color coded to show how precursors link):
The substrate of CPPase is dimethylallyl diphosphate. The two products, diphosphate and chrysanthemyl diphosphate.
This enzyme is involves in the biosynthesis of pyrethrins, highly potent insecticides found in some flowers. The systematic name of this enzyme class is dimethylallyl-diphosphate:dimethylallyl-diphosphate dimethylallyltransferase (chrysanthemyl-diphosphate-forming).
References
- Shattuck-Eidens DM, Wrobel WM, Peiser GD, Poulter CD (2001). "Chrysanthemyl diphosphate synthase: isolation of the gene and characterization of the recombinant non-head-to-tail monoterpene synthase from Chrysanthemum cinerariaefolium". Proc. Natl. Acad. Sci. U. S. A. 98 (8): 4373–8. doi:10.1073/pnas.071543598. PMC 31842. PMID 11287653. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31842.
- Erickson HK, Poulter CD (2003). "Chrysanthemyl diphosphate synthase. The relationship among chain elongation, branching, and cyclopropanation reactions in the isoprenoid biosynthetic pathway". J. Am. Chem. Soc. 125 (23): 6886–8. doi:10.1021/ja034520g. PMID 12783539.
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