Dolichol O-acyltransferase

Dolichol O-acyltransferase
dolichol O-acyltransferase
Identifiers
EC number 2.3.1.123
CAS number 111839-04-4
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dolichol O-acyltransferase (EC 2.3.1.123) is an enzyme that catalyzes the chemical reaction

palmitoyl-CoA + dolichol \rightleftharpoons CoA + dolichyl palmitate

Thus, the two substrates of this enzyme are palmitoyl-CoA and dolichol, whereas its two products are CoA and dolichyl palmitate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is palmitoyl-CoA:dolichol O-palmitoyltransferase. This enzyme is also called acyl-CoA:dolichol acyltransferase.

References

  • Tollbom O, Valtersson C, Chojnacki T, Dallner G (1988). "Esterification of dolichol in rat liver". J. Biol. Chem. 263 (3): 1347–52. PMID 3121628.