Dihydrolipoyllysine-residue acetyltransferase

In enzymology, a dihydrolipoyllysine-residue acetyltransferase (EC number|2.3.1.12) is an enzyme that catalyzes the chemical reaction

:acetyl-CoA + enzyme N₆-(dihydrolipoyl)lysine $ightleftharpoons$ CoA + enzyme N₆-(S-acetyldihydrolipoyl)lysine

Thus, the two substrates of this enzyme are acetyl-CoA and enzyme N6-(dihydrolipoyl)lysine, whereas its two products are CoA and enzyme N6-(S-acetyldihydrolipoyl)lysine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:enzyme N6-(dihydrolipoyl)lysine S-acetyltransferase. Other names in common use include acetyl-CoA:dihydrolipoamide S-acetyltransferase, dihydrolipoamide S-acetyltransferase, dihydrolipoate acetyltransferase, dihydrolipoic transacetylase, dihydrolipoyl acetyltransferase, lipoate acetyltransferase, lipoate transacetylase, lipoic acetyltransferase, lipoic acid acetyltransferase, lipoic transacetylase, lipoylacetyltransferase, thioltransacetylase A, transacetylase X, enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase, and acetyl-CoA:enzyme 6-N-(dihydrolipoyl)lysine S-acetyltransferase. This enzyme participates in 3 metabolic pathways: glycolysis / gluconeogenesis, alanine and aspartate metabolism, and pyruvate metabolism.

tructural studies

As of late 2007, 31 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B5S, PDB link|1DPB, PDB link|1DPC, PDB link|1DPD, PDB link|1EAA, PDB link|1EAB, PDB link|1EAC, PDB link|1EAD, PDB link|1EAE, PDB link|1EAF, PDB link|1FYC, PDB link|1IYU, PDB link|1IYV, PDB link|1LAB, PDB link|1LAC, PDB link|1W3D, PDB link|1W4E, PDB link|1W4F, PDB link|1W4G, PDB link|1W4H, PDB link|1W4I, PDB link|1W4J, PDB link|1W4K, PDB link|1W85, PDB link|1W88, PDB link|1Y8N, PDB link|1Y8O, PDB link|1Y8P, PDB link|2DNE, PDB link|2PNR, and PDB link|2Q8I.

References

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* McElroy, W.D. and Glass, B. (Eds.), A Symposium on the Mechanism of Enzyme Action, Johns Hopkins Press, Baltimore, 1954, p. 545-580.
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External links

::"The CAS registry number for this enzyme class is CAS registry|9032-29-5."

Gene Ontology (GO) codes