Diamine N-acetyltransferase

Diamine N-acetyltransferase
diamine N-acetyltransferase
Identifiers
EC number 2.3.1.57
CAS number 54596-36-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a diamine N-acetyltransferase (EC 2.3.1.57) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an alkane-alpha,omega-diamine \rightleftharpoons CoA + an N-acetyldiamine

Thus, the two substrates of this enzyme are acetyl-CoA and alkane-alpha,omega-diamine, whereas its two products are CoA and N-acetyldiamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase. Other names in common use include spermidine acetyltransferase, putrescine acetyltransferase, putrescine (diamine)-acetylating enzyme, diamine acetyltransferase, spermidine/spermine N1-acetyltransferase, spermidine N1-acetyltransferase, acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase, putrescine acetylase, and putrescine N-acetyltransferase. This enzyme participates in urea cycle and metabolism of amino groups.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 2B3U, 2B3V, 2B4B, 2B4D, 2B58, 2B5G, 2BEI, 2F5I, 2FXF, 2G3T, 2JEV, and 2Q4V.

References

  • Ragione FD, Pegg AE (1982). "Purification and characterization of spermidine/spermine N1-acetyltransferase from rat liver". Biochemistry. 21 (24): 6152–8. doi:10.1021/bi00267a020. PMID 7150547. 
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