Citrate (Re)-synthase

citrate (Re)-synthase
Identifiers
EC number	2.3.3.3
CAS number	9077-70-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O + oxaloacetate $\rightleftharpoons$ citrate + CoA

The 3 substrates of this enzyme are acetyl-CoA, H₂O, and oxaloacetate, whereas its two products are citrate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA].

References

• Dittbrenner S, Chowdhury AA, Gottschalk G (1969). "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate". Biochem. Biophys. Res. Commun. 36 (5): 802–8. doi:10.1016/0006-291X(69)90680-9. PMID 5808294. 
• Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7 (2): 301–6. doi:10.1111/j.1432-1033.1969.tb19607.x. PMID 4974734. 
• Gottschalk G, Barker HA (1966). "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase". Biochemistry. 5 (4): 1125–33. doi:10.1021/bi00868a003. PMID 5958189. 

This transferase article is a stub. You can help Wikipedia by expanding it.v · Categories: Transferase stubs EC 2.3.3 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? Turlogh Dubh O'Brien Llangattock-Vibon-Avel Look at other dictionaries: citrate (si)-synthase — cit·rate (si) syn·thase (sitґrāt sinґthās) [EC 2.3.3.1] an enzyme of the transferase class that catalyzes the condensation of oxaloacetate and the acetyl group of acetyl coenzyme A to form citrate and coenzyme A. This is the initial… …   Medical dictionary Citrate synthase — Identifiers Symbol CS Entrez 1431 HUGO …   Wikipedia citrate synthase — n an enzyme that catalyzes condensation of acetyl coenzyme A with oxaloacetate to form citric acid in the Krebs cycle called also citrogenase …   Medical dictionary Citrate synthase family — Citrate synt cold active citrate synthase Identifiers Symbol Citrate synt Pfam …   Wikipedia Citrate — The citrate anion A citrat …   Wikipedia Synthase — In biochemistry, a synthase is an enzyme which catalyzes a synthesis process.Following the EC number classification, they belong to the group of ligases, with lyases catalysing the reverse reaction. Examples * ATP synthase * Citrate synthase *… …   Wikipedia Synthase — Une synthase est une enzyme appartenant à la classe des ligases. Cette enzyme forme et défait des liaisons. Certaines synthases peuvent utiliser de l ATP. Exemples ATP synthase Tryptophane synthase Thymidylate synthase Acide gras synthase Citrate …   Wikipédia en Français citrate — A salt or ester of citric acid; used as anticoagulants because they bind calcium ions. c. aldolase SYN: c. lyase. ATP c. (pro 3S) lyase an enzyme that catalyzes the reaction of ATP, c., and coenzyme A to …   Medical dictionary citrate —    Formed in the citrate synthase reaction from oxaloacetate and acetyl CoA …   Forensic science glossary ATP citrate synthase — In enzymology, an ATP citrate synthase (EC number|2.3.3.8) is an enzyme that catalyzes the chemical reaction:ADP + phosphate + acetyl CoA + oxaloacetate ightleftharpoons ATP + citrate + CoAThe 4 substrates of this enzyme are ADP, phosphate,… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”