Arylamine N-acetyltransferase

Arylamine N-acetyltransferase
arylamine N-acetyltransferase
Identifiers
EC number 2.3.1.5
CAS number 9027-33-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an arylamine N-acetyltransferase (EC 2.3.1.5) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + an arylamine \rightleftharpoons CoA + an N-acetylarylamine

Thus, the two substrates of this enzyme are acetyl-CoA and arylamine, whereas its two products are CoA and N-acetylarylamine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:arylamine N-acetyltransferase. Other names in common use include arylamine acetylase, beta-naphthylamine N-acetyltransferase, 4-aminobiphenyl N-acetyltransferase, acetyl CoA-arylamine N-acetyltransferase, 2-naphthylamine N-acetyltransferase, arylamine acetyltransferase, indoleamine N-acetyltransferase, N-acetyltransferase, p-aminosalicylate N-acetyltransferase, serotonin acetyltransferase, and serotonin N-acetyltransferase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1GX3, 1W5R, 1W6F, 2BSZ, 2IJA, 2PFR, and 2PQT.

References

  • CHOU TC, LIPMANN F (1952). "Separation of acetyl transfer enzymes in pigeon liver extract". J. Biol. Chem. 196 (1): 89–103. PMID 12980945. 
  • Paul RC, Ratledge C (1973). "Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes". Biochim. Biophys. Acta. 320 (1): 9–15. PMID 4748369. 
  • Tabor H, Mehler AH and Stadtman ER (1953). "The enzymatic acetylation of amines". J. Biol. Chem. 204 (1): 127–138. PMID 13084583. 
  • Weissbach H, Redfield BG and Axelrod J (1961). "The enzymic acetylation of serotonin and other naturally occurring amines". Biochim. Biophys. Acta 54 (1): 190–192. doi:10.1016/0006-3002(61)90954-4. PMID 14005907. 
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