Protein-arginine deiminase
- Protein-arginine deiminase
In enzymology, a protein-arginine deiminase (EC number|3.5.3.15) is an enzyme that catalyzes a form of post translational modification called arginine de-imination or citrullination:
:protein L-arginine + H2O protein L-citrulline + NH3
Thus, the two substrates of this enzyme are protein L-arginine and H2O, whereas its two products are protein L-citrulline and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is protein-L-arginine iminohydrolase. This enzyme is also called peptidylarginine deiminase.
tructural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WD8, PDB link|1WD9, PDB link|1WDA, PDB link|2DEW, PDB link|2DEX, PDB link|2DEY, and PDB link|2DW5.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|75536-80-0."
Gene Ontology (GO) codes
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Look at other dictionaries:
protein-arginine deiminase — pro·tein ar·gi·nine de·im·i·nase (proґtēn ahrґjĭ nēn de imґĭ nās) [EC 3.5.3.15] EC nomenclature for peptidylarginine deiminase … Medical dictionary
peptidyl-arginine deiminase — EC 3.5.3.15 Enzyme responsible for formation of protein bound citrulline, a major amino acid in the inner root sheath and medulla of the hair follicle. Substrate is trichohyalin and postsynthetic modification of trichohylain by PAD alters its… … Dictionary of molecular biology
Arginine — An amino acid, one of the 20 amino acids that serve as the building blocks in protein. Arginine is not an essential amino acid. (It is not essential to the diet, but can be made by the body from other substances.) However, it is usually… … Medical dictionary
peptidylarginine deiminase — pep·ti·dyl·ar·gi·nine de·im·i·nase (pep″tĭ dəl ahrґjĭ nēn de imґĭ nās) a family of enzymes of the hydrolase class that catalyze the posttranslational conversion of arginine residues to citrulline residues in… … Medical dictionary
PADI4 — Peptidyl arginine deiminase, type IV PDB rendering based on 1wd8 … Wikipedia
PADI3 — Peptidyl arginine deiminase, type III Identifiers Symbols PADI3; MGC126307; MGC126308; PAD3; PDI3 External IDs … Wikipedia
PADI2 — Peptidyl arginine deiminase, type II Identifiers Symbols PADI2; KIAA0994; PAD H19; PAD2; PDI2 External IDs … Wikipedia
PADI1 — Peptidyl arginine deiminase, type I Identifiers Symbols PADI1; HPAD10; PAD1; PDI; PDI1 External IDs … Wikipedia
List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… … Wikipedia
Arginase — Liver arginase ArginasePDB 1CEV. Identifiers Symbol ARG1 … Wikipedia
