PADI2

PADI2
Peptidyl arginine deiminase, type II
Identifiers
Symbols PADI2; KIAA0994; PAD-H19; PAD2; PDI2
External IDs OMIM607935 MGI1338892 HomoloGene7214 GeneCards: PADI2 Gene
EC number 3.5.3.15
RNA expression pattern
PBB GE PADI2 209791 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11240 18600
Ensembl ENSG00000117115 ENSMUSG00000028927
UniProt Q9Y2J8 n/a
RefSeq (mRNA) NM_007365 NM_008812.2
RefSeq (protein) NP_031391 NP_032838.2
Location (UCSC) Chr 1:
17.39 – 17.45 Mb
Chr 4:
140.46 – 140.51 Mb
PubMed search [1] [2]

Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene.[1][2]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.[2]

References

  1. ^ Watanabe K, Senshu T (Oct 1989). "Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase". J Biol Chem 264 (26): 15255–60. PMID 2768262. 
  2. ^ a b "Entrez Gene: PADI2 peptidyl arginine deiminase, type II". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11240. 

Further reading


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