Peptide deformylase

In enzymology, a peptide deformylase (EC number|3.5.1.88) is an enzyme that catalyzes the chemical reaction

:formyl-L-methionyl peptide + H₂O $ightleftharpoons$ formate + methionyl peptide

Thus, the two substrates of this enzyme are formyl-L-methionyl peptide and H₂O, whereas its two products are formate and methionyl peptide.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is formyl-L-methionyl peptide amidohydrolase.

tructural studies

As of late 2007, 34 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1IX1, PDB link|1LM4, PDB link|1LM6, PDB link|1LME, PDB link|1LQW, PDB link|1LQY, PDB link|1LRU, PDB link|1LRY, PDB link|1N5N, PDB link|1Q1Y, PDB link|1S17, PDB link|1SV2, PDB link|1SZZ, PDB link|1V3Y, PDB link|1VEV, PDB link|1VEY, PDB link|1VEZ, PDB link|1WS0, PDB link|1WS1, PDB link|1XEM, PDB link|1XEN, PDB link|1XEO, PDB link|1Y6H, PDB link|1ZXZ, PDB link|1ZY0, PDB link|1ZY1, PDB link|2AI7, PDB link|2AI8, PDB link|2AI9, PDB link|2AIA, PDB link|2AIE, PDB link|2EW5, PDB link|2EW6, and PDB link|2EW7.

References

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External links

Gene Ontology (GO) codes