N-formylmethionylaminoacyl-tRNA deformylase

N-formylmethionylaminoacyl-tRNA deformylase
N-formylmethionylaminoacyl-tRNA deformylase
Identifiers
EC number 3.5.1.27
CAS number 37289-08-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-formylmethionylaminoacyl-tRNA deformylase (EC 3.5.1.27) is an enzyme that catalyzes the chemical reaction

N-formyl-L-methionylaminoacyl-tRNA + H2O \rightleftharpoons formate + L-methionylaminoacyl-tRNA

Thus, the two substrates of this enzyme are N-formyl-L-methionylaminoacyl-tRNA and H2O, whereas its two products are formate and L-methionylaminoacyl-tRNA.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-formyl-L-methionylaminoacyl-tRNA amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1BSJ, 1BSK, and 1LMH.

References

  • Livingston DM, Leder P (1969). "Deformylation and protein biosynthesis". Biochemistry. 8 (1): 435–43. doi:10.1021/bi00829a059. PMID 4887858. 
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