- N-methyl-2-oxoglutaramate hydrolase
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N-methyl-2-oxoglutaramate hydrolase Identifiers EC number 3.5.1.36 CAS number 9073-53-4 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a N-methyl-2-oxoglutaramate hydrolase (EC 3.5.1.36) is an enzyme that catalyzes the chemical reaction
- N-methyl-2-oxoglutaramate + H2O
2-oxoglutarate + methylamine
Thus, the two substrates of this enzyme are N-methyl-2-oxoglutaramate and H2O, whereas its two products are 2-oxoglutarate and methylamine.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-methyl-2-oxoglutaramate methylamidohydrolase. This enzyme is also called 5-hydroxy-N-methylpyroglutamate synthase.
References
- Hersh LB (1970). "5-hydroxy-N-methylpyroglutamate synthetase. Purification and mechanism of action". J. Biol. Chem. 245 (14): 3526–35. PMID 5470822.
- Hersh LB, Tsai L, Stadtman ER (1969). "The enzymatic synthesis of 5-hydroxy-N-methylpyroglutamic acid". J. Biol. Chem. 244 (17): 4677–83. PMID 5808511.
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