N-malonylurea hydrolase

N-malonylurea hydrolase
N-malonylurea hydrolase
Identifiers
EC number 3.5.1.95
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a N-malonylurea hydrolase (EC 3.5.1.95) is an enzyme that catalyzes the chemical reaction

3-oxo-3-ureidopropanoate + H2O \rightleftharpoons malonate + urea

Thus, the two substrates of this enzyme are 3-oxo-3-ureidopropanoate and H2O, whereas its two products are malonate and urea.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 3-oxo-3-ureidopropanoate amidohydrolase (urea- and malonate-forming). This enzyme is also called ureidomalonase.

References

  • Soong CL, Ogawa J, Shimizu S (2001). "Novel amidohydrolytic reactions in oxidative pyrimidine metabolism: analysis of the barbiturase reaction and discovery of a novel enzyme, ureidomalonase". Biochem. Biophys. Res. Commun. 286 (1): 222–6. doi:10.1006/bbrc.2001.5356. PMID 11485332. 
  • Soong CL, Ogawa J, Sakuradani E, Shimizu S (2002). "Barbiturase, a novel zinc-containing amidohydrolase involved in oxidative pyrimidine metabolism". J. Biol. Chem. 277 (9): 7051–8. doi:10.1074/jbc.M110784200. PMID 11748240. 
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