Maleimide hydrolase

maleimide hydrolase
Identifiers
EC number	3.5.2.16
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a maleimide hydrolase (EC 3.5.2.16) is an enzyme that catalyzes the chemical reaction

maleimide + H₂O $\rightleftharpoons$ maleamic acid

Thus, the two substrates of this enzyme are maleimide and H₂O, whereas its product is maleamic acid.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is cyclic-imide amidohydrolase (decyclizing). Other names in common use include imidase, cyclic imide hydrolase, and cyclic-imide amidohydrolase (decyclicizing) [misprint].

References

• Ogawa J, Soong CL, Honda M, Shimizu S (1997). "Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides". Eur. J. Biochem. 243 (1–2): 322–7. doi:10.1111/j.1432-1033.1997.0322a.x. PMID 9030755. 

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