2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase
Identifiers
EC number	3.5.1.66
CAS number	95829-26-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a 2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase (EC 3.5.1.66) is an enzyme that catalyzes the chemical reaction

2-(hydroxymethyl)-3-(acetamidomethylene)succinate + 2 H₂O $\rightleftharpoons$ acetate + 2-(hydroxymethyl)-4-oxobutanoate + NH₃ + CO₂

Thus, the two substrates of this enzyme are 2-(hydroxymethyl)-3-(acetamidomethylene)succinate and H₂O, whereas its 4 products are acetate, 2-(hydroxymethyl)-4-oxobutanoate, NH₃, and CO₂.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(hydroxymethyl)-3-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). Other names in common use include compound B hydrolase, alpha-hydroxymethyl-alpha'-(N-acetylaminomethylene)succinic acid, and hydrolase. This enzyme participates in vitamin B₆ metabolism.

References

• Huynh MS, Snell EE (1985). "Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260 (4): 2379–83. PMID 3972793. 

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase stubs EC 3.5.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужен реферат? 2-aminomuconate deaminase Cimdenieki Look at other dictionaries: Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia EC 3.5 — Le groupe EC3.5 rassemble des enzymes appartenant à la famille des hydrolases. Elles ont pour particularité de catalyser des réactions d hydrolyse dans des molécules possédant un carbone et un azote liés par liaison simple, double ou triple. À la …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”