Nucleoside-triphosphate diphosphatase

nucleoside-triphosphate diphosphatase
Identifiers
EC number	3.6.1.19
CAS number	9075-54-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nucleoside-triphosphate diphosphatase (EC 3.6.1.19) is an enzyme that catalyzes the chemical reaction

a nucleoside triphosphate + H₂O $\rightleftharpoons$ a nucleotide + diphosphate

Thus, the two substrates of this enzyme are nucleoside triphosphate and H₂O, whereas its two products are nucleotide and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is nucleoside-triphosphate diphosphohydrolase. This enzyme is also called nucleoside-triphosphate pyrophosphatase. This enzyme participates in purine metabolism and pyrimidine metabolism.

Structural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1V7R, 2CAR, 2E5X, 2I5D, and 2J4E.

References

• Chern CJ, MacDonald AB, Morris AJ (1969). "Purification and properties of a nucleoside triphosphate pyrophosphohydrolase from red cells of the rabbit". J. Biol. Chem. 244 (20): 5489–95. PMID 4310599. 

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