DUTP diphosphatase

DUTP diphosphatase

In enzymology, a dUTP diphosphatase (EC number|3.6.1.23) is an enzyme that catalyzes the chemical reaction

:dUTP + H2O ightleftharpoons dUMP + diphosphate

Thus, the two substrates of this enzyme are dUTP and H2O, whereas its two products are dUMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dUTP nucleotidohydrolase. Other names in common use include deoxyuridine-triphosphatase, dUTPase, dUTP pyrophosphatase, desoxyuridine 5'-triphosphate nucleotidohydrolase, and desoxyuridine 5'-triphosphatase. This enzyme participates in pyrimidine metabolism.

The main function of this enzyme is to remove dUTP from the deoxynucleotide pool, which reduces the probability of this base being mistakenly incorporated into DNA by DNA polymerases, which is a cause of mutations. [cite journal |author=Vassylyev DG, Morikawa K |title=Precluding uracil from DNA |journal=Structure |volume=4 |issue=12 |pages=1381–5 |year=1996 |pmid=8994964 |doi=10.1016/S0969-2126(96)00145-1]

tructural studies

As of late 2007, 48 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1DUC, PDB link|1DUD, PDB link|1DUN, PDB link|1DUP, PDB link|1DUT, PDB link|1EU5, PDB link|1EUW, PDB link|1F7D, PDB link|1F7K, PDB link|1F7N, PDB link|1F7O, PDB link|1F7P, PDB link|1F7Q, PDB link|1F7R, PDB link|1MQ7, PDB link|1OGH, PDB link|1OGK, PDB link|1OGL, PDB link|1PKH, PDB link|1PKJ, PDB link|1PKK, PDB link|1RN8, PDB link|1RNJ, PDB link|1SEH, PDB link|1SIX, PDB link|1SJN, PDB link|1SLH, PDB link|1SM8, PDB link|1SMC, PDB link|1SNF, PDB link|1SYL, PDB link|1VYQ, PDB link|1W2Y, PDB link|2BSY, PDB link|2BT1, PDB link|2CJE, PDB link|2D4L, PDB link|2D4M, PDB link|2D4N, PDB link|2HQU, PDB link|2HR6, PDB link|2HRM, PDB link|2OKB, PDB link|2OKD, PDB link|2OKE, PDB link|2OL0, PDB link|2OL1, and PDB link|2PY4.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37289-34-2."

Gene Ontology (GO) codes


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