Bis(5'-adenosyl)-triphosphatase

Bis(5'-adenosyl)-triphosphatase

In enzymology, a bis(5'-adenosyl)-triphosphatase (EC number|3.6.1.29) is an enzyme that catalyzes the chemical reaction

:P1,P3-bis(5'-adenosyl) triphosphate + H2O ightleftharpoons ADP + AMP

Thus, the two substrates of this enzyme are P1,P3-bis(5'-adenosyl) triphosphate and H2O, whereas its two products are ADP and AMP.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase. Other names in common use include dinucleosidetriphosphatase, diadenosine 5,5-P1,P3-triphosphatase, and 1-P,3-P-bis(5'-adenosyl)-triphosphate adenylohydrolase. This enzyme participates metabolic pathways involved in purine metabolism, and may have a role in the development of small cell lung cancer, and non-small cell lung cancer.

tructural studies

As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1FHI, PDB link|2FHI, PDB link|4FIT, PDB link|5FIT, and PDB link|6FIT.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|63951-94-0."

Gene Ontology (GO) codes


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  • List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia

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